9PIB image
Deposition Date 2025-07-10
Release Date 2026-03-18
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9PIB
Keywords:
VIRAL PROTEIN
Title:
Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with fusion inhibitor CLIPS peptide CP121132 (CP-S1)
Biological Source:
Source Organism(s):
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (Taxon ID: 211044)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Trichoplusia ni
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.35 Å
R-Value Free:
0.23
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 3
9PIB validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Hemagglutinin
Gene (Uniprot):HA
Chain IDs:A, C, E, G
Chain Length:326
Number of Molecules:4
Biological Source:Influenza A virus (A/Puerto Rico/8/1934(H1N1))
UniProt ID:P03452 Pfam ID:PF00509
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Hemagglutinin HA2 chain
Gene (Uniprot):HA
Chain IDs:B, D, F, H
Chain Length:176
Number of Molecules:4
Biological Source:Influenza A virus (A/Puerto Rico/8/1934(H1N1))
UniProt ID:P03452 Pfam ID:PF00509
Polymer Type:polypeptide(L)
Molecule:CLIPS peptide CP121132
Chain IDs:I (auth: N), J (auth: O), K (auth: P), L (auth: Q)
Chain Length:13
Number of Molecules:4
Biological Source:synthetic construct
Ligand Molecules
FUC
NAG
PEG
SEZ
Primary Citation
Small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins.
Proc.Natl.Acad.Sci.USA 123 e2537533123 e2537533123 (2026)
PMID: 41875158 DOI: 10.1073/pnas.2537533123
Primary Citation of related structures
9PIB
Feedback Form
Name
Email
Institute
Feedback