ISDA: 9OZG

Deposition Date 2025-06-05

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9OZG

Keywords:

OXIDOREDUCTASE

Title:

1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Acinetobacter baumannii in complex with a Fosmidomycin analog, NADPH, and a magnesium ion

Biological Source:

Source Organism(s):

Acinetobacter baumannii (Taxon ID: 470)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.20

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 2 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:1-deoxy-D-xylulose 5-phosphat
Chain IDs:A
Chain Length:406
Number of Molecules:1
Biological Source:Acinetobacter baumannii

Ligand Molecules

A1CE6

EDO

NDP

Primary Citation

Structure-Activity Relationships among Inhibitors of Acinetobacter baumannii and Klebsiella pneumoniae 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR/IspC) - A Promising Target for Antibiotic Development.

Girma, M, Dufrisne, M.B, Sehgal, A, Dailey, A, Heidel, K, Bague, D, Wang, X, Bartholomew, L, Beck, R, Kirby, S, Ball, H, Zainab, M, Lee, S.H, Soojhawon, I, Noble, S.M, Dowd, C.S, Couch, R.D.Show

Acs Infect Dis. ? ? ? (2026)

PMID: 41816984 DOI: 10.1021/acsinfecdis.5c00875

Primary Citation of related structures

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