ISDA: 9OLL

Deposition Date 2025-05-12

Release Date 2026-03-25

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9OLL

Keywords:

MEMBRANE PROTEIN

Title:

Structure of human TRPC3 T573A mutant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Short transient receptor pote
Gene (Uniprot):TRPC3
Mutagens:T573A
Chain IDs:A, B, C, D
Chain Length:848
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q13507 Pfam ID:PF08344, PF00520

Ligand Molecules

CPL

Primary Citation

Functional and structural basis of a hypermorphic TRPC3 variant.

Bell, B, Jaramillo-Granada, A.M, Romero, L.O, Gutierrez, I.A, Mallampalli, V.K.P.S, Fan, G, Varma, S, Baker, M.L, Serysheva, I.I, Vasquez, V, Cordero-Morales, J.F.Show

Sci Adv 12 eaec9284 eaec9284 (2026)

PMID: 41880503 DOI: 10.1126/sciadv.aec9284

Primary Citation of related structures

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