9OCG image
Deposition Date 2025-04-24
Release Date 2025-09-10
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9OCG
Keywords:
MEMBRANE PROTEIN
Title:
Transporter associated with antigen processing (TAP) bound to the viral protein BNLF2a in the inward-facing state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
human gammaherpesvirus 4 (Taxon ID: 10376)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.80 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OCG validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antigen peptide transporter 1
Gene (Uniprot):TAP1
Chain IDs:C (auth: A)
Chain Length:887
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q03518 Pfam ID:PF00664, PF00005 EC:7.4.2.14
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antigen peptide transporter 2
Gene (Uniprot):TAP2
Chain IDs:A (auth: B)
Chain Length:686
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q03519 Pfam ID:PF00664, PF00005 EC:7.4.2.14
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:TAP transport inhibitor BNLF2
Gene (Uniprot):BNLF2a
Chain IDs:B (auth: C)
Chain Length:95
Number of Molecules:1
Biological Source:human gammaherpesvirus 4
UniProt ID:P0C737
Ligand Molecules
NA
Primary Citation
Structurally diverse viral inhibitors converge on a shared mechanism to stall the antigen transporter TAP.
Proc.Natl.Acad.Sci.USA 122 e2516676122 e2516676122 (2025)
PMID: 40956880 DOI: 10.1073/pnas.2516676122
Primary Citation of related structures
9OCG
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