ISDA: 9O8E

Deposition Date 2025-04-15

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9O8E

Keywords:

PROTEIN FIBRIL

Title:

amyloid fibril of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer's disease tau fibrils

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform Tau-F of Microtubule-
Gene (Uniprot):MAPT
Chain IDs:A, B, C, D, E
Chain Length:449
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:P10636 Pfam ID:PF00418

Ligand Molecules

Primary Citation

RNA contributes to polymorphism of tau amyloid fibrils

Abskharon, R, Jiang, Y.X, Ge, P, Sawaya, M.R, Zhang, J, Boyer, D.R, Dolinsky, J.L, Cascio, D, Guo, F, Eisenberg, D.S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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