ISDA: 9NW6

Deposition Date 2025-03-21

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9NW6

Keywords:

IMMUNE SYSTEM

Title:

CA147v24 Fab bound to HLA-E-VL9

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.10 Å

R-Value Free:

0.25

R-Value Work:

0.23

R-Value Observed:

0.24

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:HLA class I histocompatibilit
Gene (Uniprot):HLA-E
Chain IDs:A, C
Chain Length:275
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P13747 Pfam ID:PF00129, PF07654

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:B, D
Chain Length:100
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61769 Pfam ID:PF07654

Polymer Type:polypeptide(L)
Molecule:CA147v24 heavy chain
Chain IDs:E, G
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:VL9 peptide
Gene (Uniprot):HLA-A
Chain IDs:F, J (auth: P)
Chain Length:9
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P04439

Polymer Type:polypeptide(L)
Molecule:CA147v24 light chain
Chain IDs:H, I
Chain Length:214
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

HLA-E-VL9 antibodies mediate NKG2A+ NK cell and CD8+ T cell killing of HIV-infected CD4+ T cells

Hwang, J.K, Marston, D.J, Tuyishime, M, Yang, H, Wrapp, D, Li, D, Brackenridge, S, Frazier, M, Rhodes, B, Harris, C, Quastel, M, Kapingidza, A.B, Gater, J, Borrow, P, Gillespie, G.M, Ferrari, G, McMichael, A.J, Haynes, B.F, Azoitei, M.L.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form