9NP0 image
Deposition Date 2025-03-10
Release Date 2026-04-01
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9NP0
Keywords:
PROTEIN BINDING/IMMUNE SYSTEM
Title:
Structure of human annexin A1 in complex with 2C1 Fab
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Escherichia coli, Mus musculus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.32 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9NP0 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Annexin A1
Gene (Uniprot):ANXA1
Chain IDs:A
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P04083 Pfam ID:PF00191
Polymer Type:polypeptide(L)
Molecule:2C1 Fab heavy chain
Chain IDs:B
Chain Length:225
Number of Molecules:1
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:2C1 Fab light chain
Chain IDs:C
Chain Length:212
Number of Molecules:1
Biological Source:Mus musculus
Ligand Molecules
NA
Primary Citation
Annexin A1 plays an essential dual role throughout neoplastic progression by stimulating tumor growth and modulating immune microenvironment via direct binding of beta-catenin
To Be Published ? ? ? (?)
Primary Citation of related structures
9NP0
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