ISDA: 9NC0

Deposition Date 2025-02-14

Release Date 2026-01-21

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9NC0

Keywords:

IMMUNE SYSTEM

Title:

AMC008 v4.2 SOSIP Env trimer in complex with b12 Fab

Biological Source:

Source Organism(s):

Human immunodeficiency virus 1 (Taxon ID: 11676)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.88 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein gp120
Chain IDs:A, E (auth: C), I (auth: E)
Chain Length:488
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Envelope glycoprotein gp41
Gene (Uniprot):env
Chain IDs:B, F (auth: D), J (auth: F)
Chain Length:154
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

UniProt ID:Q1AII4

Polymer Type:polypeptide(L)
Molecule:b12 Fab heavy chain
Chain IDs:C (auth: H), G, K (auth: J)
Chain Length:230
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:b12 Fab light chain
Chain IDs:D (auth: L), H (auth: I), L (auth: K)
Chain Length:215
Number of Molecules:3
Biological Source:Homo sapiens

Ligand Molecules

NAG

Primary Citation

Conformational landscape of HIV-1 Env from closed to fully open.

Cui, J, Lin, Z.J, Ghosh, S, Du, J, Sadeesh, R, Weiner, D.B, Pallesen, J.Show

Nat Commun ? ? ? (2026)

PMID: 41735302 DOI: 10.1038/s41467-026-69921-z

Primary Citation of related structures

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