9MWP image
Deposition Date 2025-01-17
Release Date 2025-11-26
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9MWP
Keywords:
Title:
Structure of human endothelial nitric oxide synthase heme domain bound with N-(4-(2-((3-(furan-3-carboximidamido)benzyl)amino)ethyl)phenyl)furan-3-carboximidamide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
1.86 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.18
Space Group:
P 21 21 21
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nitric oxide synthase 3
Gene (Uniprot):NOS3
Chain IDs:A, B
Chain Length:441
Number of Molecules:2
Biological Source:Homo sapiens
Primary Citation
New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma.
J.Med.Chem. 69 2310 2329 (2026)
PMID: 41615895 DOI: 10.1021/acs.jmedchem.5c02154
Primary Citation of related structures
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