9MJA image
Deposition Date 2024-12-14
Release Date 2026-01-21
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9MJA
Keywords:
DNA BINDING PROTEIN
Title:
PARP1 ART in complex with HPF1 and EB47
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9MJA validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Poly [ADP-ribose] polymerase
Gene (Uniprot):PARP1
Chain IDs:A
Chain Length:1034
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P09874 Pfam ID:PF00645, PF21728, PF08063, PF00533, PF05406, PF02877, PF00644 EC:2.4.2.30
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Histone PARylation factor 1
Gene (Uniprot):HPF1
Chain IDs:B
Chain Length:347
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NWY4 Pfam ID:PF10228
Ligand Molecules
UHB
Primary Citation
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation.
Nat Commun 17 ? ? (2026)
PMID: 41698892 DOI: 10.1038/s41467-026-69375-3
Primary Citation of related structures
9MJA
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