9MET image
Deposition Date 2024-12-08
Release Date 2025-09-10
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9MET
Keywords:
SIGNALING PROTEIN
Title:
CXCR4-HIV-2/gp120-CD4
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Virus-associated RNAs (Taxon ID: 1425366)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
5.65 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9MET validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:C-X-C chemokine receptor type
Gene (Uniprot):CXCR4
Chain IDs:A (auth: M), B (auth: N), C (auth: O), D (auth: S)
Chain Length:360
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P61073 Pfam ID:PF12109, PF00001
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:T-cell surface glycoprotein C
Gene (Uniprot):CD4
Chain IDs:E (auth: R), G (auth: A)
Chain Length:176
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P01730 Pfam ID:PF00047, PF05790
Polymer Type:polypeptide(L)
Molecule:HIV-1/gp120
Chain IDs:F (auth: T), H (auth: Q)
Chain Length:479
Number of Molecules:2
Biological Source:Virus-associated RNAs
Ligand Molecules
NA
Primary Citation
CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12.
Nat Commun 16 8653 8653 (2025)
PMID: 41027939 DOI: 10.1038/s41467-025-63815-2
Primary Citation of related structures
9MET
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