9MEJ image
Deposition Date 2024-12-06
Release Date 2025-09-10
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9MEJ
Keywords:
SIGNALING PROTEIN
Title:
Global structure of hCXCR4 and HIV-2 gp120
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Human immunodeficiency virus 2 (Taxon ID: 11709)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.99 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9MEJ validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:C-X-C chemokine receptor type
Gene (Uniprot):CXCR4
Chain IDs:A, B, C, D
Chain Length:360
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P61073 Pfam ID:PF12109, PF00001
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:gp120
Gene (Uniprot):env
Chain IDs:E
Chain Length:479
Number of Molecules:1
Biological Source:Human immunodeficiency virus 2
UniProt ID:B2LT42 Pfam ID:PF00516
Ligand Molecules
NA
Primary Citation
CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12.
Nat Commun 16 8653 8653 (2025)
PMID: 41027939 DOI: 10.1038/s41467-025-63815-2
Primary Citation of related structures
9MEJ
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