ISDA: 9MAR

Deposition Date 2025-03-14

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9MAR

Keywords:

HYDROLASE

Title:

Serine Beta Lactamase OXA-48 in Complex with Dual MBL/SBL Inhibitor 19

Biological Source:

Source Organism(s):

Klebsiella pneumoniae (Taxon ID: 573)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.37 Å

R-Value Free:

0.25

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-lactamase OXA-48
Gene (Uniprot):OXA-48
Chain IDs:A, B, C, D
Chain Length:265
Number of Molecules:4
Biological Source:Klebsiella pneumoniae

UniProt ID:Q6XEC0 EC:3.5.2.6

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
KCX	A	LYS	modified residue

Ligand Molecules

A1ENI

Primary Citation

Structural Optimization of Bicyclic Oxoboronates as Dual Metallo and Serine BetaLactamase Inhibitors

Li, G.-B, Yang, Z.-B.Show

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