ISDA: 9LY6

Deposition Date 2025-02-19

Release Date 2026-03-04

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9LY6

Keywords:

ANTITUMOR PROTEIN/IMMUNE SYSTEM

Title:

antibody 20G5 (Fab')2 in complex with human B7-H3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.67 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:CD276 antigen
Gene (Uniprot):CD276
Chain IDs:A
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q5ZPR3 Pfam ID:PF07686, PF22705

Polymer Type:polypeptide(L)
Molecule:antibody 20G5 Fab heavy chain
Chain IDs:B, D
Chain Length:237
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:antibody 20G5 Fab light chain
Chain IDs:C, E
Chain Length:213
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities.

Guan, J, Chia, T, Li, B, Zhu, T, Liao, Z, Deng, J, Fu, F, Wu, W, Liu, C, Liu, Y, Li, N, Yue, L, Cao, L, Lu, J, Zhu, M, Ling, X, Zheng, H, Lin, S, Li, L, Zhou, S, He, K.Show

Nat Commun ? ? ? (2026)

PMID: 41735305 DOI: 10.1038/s41467-026-69703-7

Primary Citation of related structures

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