9LY5 image
Deposition Date 2025-02-19
Release Date 2026-03-04
Last Version Date 2026-03-11
Entry Detail
PDB ID:
9LY5
Keywords:
ANTITUMOR PROTEIN/IMMUNE SYSTEM
Title:
antibody 20G5 Fab in complex with human B7-H3 (IgC)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.98 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9LY5 validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:antibody 20G5 Fab heavy chain
Chain IDs:A
Chain Length:223
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:antibody 20G5 Fab light chain
Chain IDs:B
Chain Length:213
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:CD276 antigen
Gene (Uniprot):CD276
Chain IDs:C
Chain Length:448
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q5ZPR3 Pfam ID:PF07686, PF22705
Ligand Molecules
NA
Primary Citation
B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities.
Nat Commun ? ? ? (2026)
PMID: 41735305 DOI: 10.1038/s41467-026-69703-7
Primary Citation of related structures
9LY5
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