ISDA: 9LWY

Deposition Date 2025-02-17

Release Date 2026-03-04

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9LWY

Keywords:

DNA BINDING PROTEIN

Title:

Crystal structure of human WDR5 in complex with compound 4

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.55 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:A
Chain Length:334
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61964 Pfam ID:PF25175

Ligand Molecules

A1EMB

GOL

Primary Citation

DeepDegradome: A Structure-Aware Deep Learning Framework for PROTAC and Ligand Generation Against Protein Targets

Hu, J.Y, Cao, Y, Zhang, X.L, Bai, F.Show

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