ISDA: 9LSZ

Deposition Date 2025-02-05

Release Date 2026-02-18

Last Version Date 2026-02-18

Entry Detail

PDB ID:

9LSZ

Keywords:

TRANSPORT PROTEIN

Title:

Inward-open Structure of human B0AT1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.11 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium-dependent neutral amin
Gene (Uniprot):SLC6A19
Chain IDs:A
Chain Length:614
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q695T7 Pfam ID:PF00209

Polymer Type:polypeptide(L)
Molecule:Antibody Fab Heavy chain
Chain IDs:C (auth: H)
Chain Length:335
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Antibody Fab Light chain
Chain IDs:B (auth: L)
Chain Length:225
Number of Molecules:1
Biological Source:Mus musculus

Ligand Molecules

Primary Citation

Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria

Imazu, T, Akashi, T, Hiraizumi, M, Inui, Y, Sasaki, W, Takahashi, T, Todoroki, H, Kumanomidou, T, Hisano, H, Asada, H, Kusakizako, T, Nishizawa, T, Iwata, S, Nureki, O, Miyaguchi, I.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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