ISDA: 9LRO

Deposition Date 2025-02-01

Release Date 2026-03-11

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9LRO

Keywords:

HYDROLASE

Title:

The crystal structure of PDE4D with T3700

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3',5'-cyclic-AMP phosphodiest
Gene (Uniprot):PDE4D
Chain IDs:A, B
Chain Length:335
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q08499 Pfam ID:PF00233 EC:3.1.4.53

Ligand Molecules

A1ELI

SO4

Primary Citation

Artificial Intelligence-Driven Discovery of Pyrazolo[1,5- a ]pyrimidine Derivatives as Novel Phosphodiesterase 4 Inhibitors for Treating Idiopathic Pulmonary Fibrosis.

Li, Z, Huan, W, Liu, X, Zhang, K, Wang, X, Huang, Y, Zhou, Q, Huang, S, Sang, Z, Luo, H.B.Show

J.Med.Chem. 68 24436 24455 (2025)

PMID: 41252469 DOI: 10.1021/acs.jmedchem.5c02407

Primary Citation of related structures

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