ISDA: 9LR2

Deposition Date 2025-01-28

Release Date 2026-02-04

Last Version Date 2026-02-04

Entry Detail

PDB ID:

9LR2

Keywords:

STRUCTURAL PROTEIN

Title:

Cryo-EM structure of the JN241-9-bound APLNR dimer-Gi complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda, Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:F (auth: B)
Chain Length:345
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Polymer Type:polypeptide(L)
Molecule:JN241-9
Chain IDs:D, E (auth: C)
Chain Length:130
Number of Molecules:2
Biological Source:synthetic construct

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:G
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Apelin receptor
Gene (Uniprot):APLNR
Chain IDs:B (auth: R), C (auth: Q)
Chain Length:380
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P35414 Pfam ID:PF00001

Polymer Type:polypeptide(L)
Molecule:single Fab chain(scFv16)
Chain IDs:H (auth: S)
Chain Length:250
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules