ISDA: 9KVJ

Deposition Date 2024-12-05

Release Date 2025-12-10

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9KVJ

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of SARS-CoV-2 BA.5 spike protein in complex with nAb 1C4 (local refinement)

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.82 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Heavy chain of nAb 1C4
Chain IDs:A (auth: C)
Chain Length:119
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Light chain of nAb 1C4
Chain IDs:B (auth: D)
Chain Length:107
Number of Molecules:1
Biological Source:Mus musculus

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:C (auth: G)
Chain Length:196
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC2 Pfam ID:PF09408

Ligand Molecules

Primary Citation

Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion.

Sun, H, Jiang, Y, Lan, M, Zhou, M, Yi, G, Shen, J, Deng, T, Liu, L, Huang, Y, Li, Y, Su, J, Lin, Y, Chen, Z, Zhou, L, Li, T, Yu, H, Cheng, T, Zhang, Y, Yuan, L, Li, S, Gu, Y, Zhang, P, Xia, N, Zheng, Q.Show

Plos Pathog. 21 e1013744 e1013744 (2025)

PMID: 41359663 DOI: 10.1371/journal.ppat.1013744

Primary Citation of related structures

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