ISDA: 9JKR

Deposition Date 2024-09-17

Release Date 2026-03-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

9JKR

Keywords:

IMMUNE SYSTEM

Title:

human GM-CSF with Fabs from autoantibodies, F1 and C.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.70 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Fab region of F1 antibody hea
Chain IDs:A
Chain Length:231
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Fab region of F1 antibody lig
Chain IDs:B
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Fab region of C antibody heav
Chain IDs:C
Chain Length:236
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Fab region of C antibody ligh
Chain IDs:D
Chain Length:221
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Granulocyte-macrophage colony
Gene (Uniprot):CSF2
Chain IDs:E (auth: I)
Chain Length:149
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P04141 Pfam ID:PF01109

Ligand Molecules

Primary Citation

Mechanism of GM-CSF autoantibody-induced pathogenicity in autoimmune pulmonary alveolar proteinosis

Futami, S, Kawai, C, Kishikawa, J, Hirose, M, Kida, H, Wang, P.H, Yamashita, K, Ishikawa, F, Kato, T, Inoue, Y, Kumanogoh, A, Kurosaki, T, Inoue, T.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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