ISDA: 9JI9

Deposition Date 2024-09-11

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9JI9

Keywords:

DNA

Title:

Solution structure of MET promoter G-quadruplex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

100

Conformers Submitted:

Selection Criteria:

structures with the lowest energy

Download Validation Report

Macromolecular Entities

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(*TP*GP*CP*GP*GP*GP*
Chain IDs:A (auth: X)
Chain Length:25
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Natural alkaloid nitidine stabilizes the major MET promoter G-quadruplex to disrupt its interaction with LRPPRC protein for MET oncogene downregulation

Li, Y.P, Zheng, Y, Wang, Y.Y, Chen, X.Y, Chen, R.S, Li, J.Z, Liu, Y.S, Yang, M.H, Zhang, H, Kong, L.Y, Wang, K.B.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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