9I64 image
Deposition Date 2025-01-29
Release Date 2026-02-18
Last Version Date 2026-02-18
Entry Detail
PDB ID:
9I64
Keywords:
TRANSCRIPTION
Title:
Crystal structure of Casdatifan bound to HIF2a-B*:ARNT-B* complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.56 Å
R-Value Free:
0.21
R-Value Work:
0.19
Space Group:
P 21 21 21
9I64 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Endothelial PAS domain-contai
Gene (Uniprot):EPAS1
Chain IDs:A
Chain Length:112
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99814 Pfam ID:PF14598
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Aryl hydrocarbon receptor nuc
Gene (Uniprot):ARNT
Chain IDs:B
Chain Length:116
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P27540 Pfam ID:PF14598
Ligand Molecules
A1I0H
FMT
MG
Primary Citation
Discovery of Casdatifan Part II, A Potent and Orally Bioavailable Inhibitor of Hypoxia Inducible Factor-2a
To Be Published ? ? ? (?)
Primary Citation of related structures
9I64
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