ISDA: 9HMR

Deposition Date 2024-12-09

Release Date 2025-12-24

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9HMR

Keywords:

HYDROLASE

Title:

KRAS-G12V-D92C covalently bound to BI-1830

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.50 Å

R-Value Free:

0.23

R-Value Work:

0.20

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Chain IDs:A, B, C, D
Chain Length:170
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

A1IWE

EDO

GDP

Primary Citation

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS.

van Tienen, L.M, Bayoumi, S, Muneeruddin, K, Leymarie, N, Popa, A, Shekhar, M, Mueller, M, Li, R, Zak, K.M, Chilukuri, H, Kornfilt, D.J.P, Atack, T.C, Kesar, D, Bian, Y, Shaw, K.L, Jandova, Z, Trollmann, P, Geist, L, Stolt-Bergner, P, Rumpel, K, Kessler, D, Sellers, W.R.Show

Cell Chem Biol 33 241 255.e8 (2026)

PMID: 41679298 DOI: 10.1016/j.chembiol.2026.01.007

Primary Citation of related structures

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