ISDA: 9HLG

Deposition Date 2024-12-04

Release Date 2025-12-17

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9HLG

Keywords:

VIRAL PROTEIN

Title:

Influenza Neuraminidase in complex with N-Acyl Oseltamivir inhibitor

Biological Source:

Source Organism(s):

Influenza A virus (Taxon ID: 11320)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Neuraminidase
Gene (Uniprot):NA
Chain IDs:A, B, C, D
Chain Length:387
Number of Molecules:4
Biological Source:Influenza A virus

UniProt ID:C7FH46 Pfam ID:PF00064 EC:3.2.1.18

Ligand Molecules

A1IVV

NAG

Primary Citation

Oseltamivir aziridines are potent influenza neuraminidase inhibitors and imaging agents.

Vriends, M.B.L, Moran, E, Calvelo, M, Hansen, T, Pickles, I.B, Xin, X, Biezeno, M, Armstrong, Z.W.B, Ferraz, M.J, Li, L, Lilley, A, Harvey, R, Filippov, D.V, Liao, Q, Schroder, S.P, van der Marel, G.A, Artola, M, Aerts, J.M.F.G, Blaza, J.N, Codee, J.D.C, Rovira, C, Overkleeft, H.S, Davies, G.J.Show

Proc.Natl.Acad.Sci.USA 123 e2504045123 e2504045123 (2026)

PMID: 41871250 DOI: 10.1073/pnas.2504045123

Primary Citation of related structures

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