ISDA: 9HIW

Deposition Date 2024-11-27

Release Date 2025-08-20

Last Version Date 2026-03-04

Entry Detail

PDB ID:

9HIW

Keywords:

CELL CYCLE

Title:

Cryo-EM structure of CDK2-cyclin A bound to a SAMHD1 peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cyclin-A2
Gene (Uniprot):CCNA2
Chain IDs:A
Chain Length:432
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P20248 Pfam ID:PF16500, PF00134, PF02984

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cyclin-dependent kinase 2
Gene (Uniprot):CDK2
Chain IDs:B
Chain Length:297
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P24941 Pfam ID:PF00069 EC:2.7.11.22

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Deoxynucleoside triphosphate
Gene (Uniprot):SAMHD1
Chain IDs:C
Chain Length:13
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y3Z3 EC:3.1.5.B1

Ligand Molecules

Primary Citation

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants.

Ord, M, Winters, M.J, Subbanna, M.S, de Martin Garrido, N, Cushing, V.I, Kliche, J, Benz, C, Ivarsson, Y, Greber, B.J, Pryciak, P.M, Davey, N.E.Show

Nat Commun 16 7622 7622 (2025)

PMID: 40817109 DOI: 10.1038/s41467-025-62765-z

Primary Citation of related structures

Feedback Form