9HIU image
Deposition Date 2024-11-27
Release Date 2025-08-20
Last Version Date 2026-03-04
Entry Detail
PDB ID:
9HIU
Keywords:
CELL CYCLE
Title:
Cryo-EM structure of CDK2-cyclin A bound to a GMNC peptide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9HIU validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclin-A2
Gene (Uniprot):CCNA2
Chain IDs:A
Chain Length:432
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P20248 Pfam ID:PF16500, PF02984, PF00134
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclin-dependent kinase 2
Gene (Uniprot):CDK2
Chain IDs:B
Chain Length:297
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P24941 Pfam ID:PF00069 EC:2.7.11.22
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Geminin coiled-coil domain-co
Gene (Uniprot):GMNC
Chain IDs:C
Chain Length:13
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A6NCL1
Ligand Molecules
NA
Primary Citation
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants.
Nat Commun 16 7622 7622 (2025)
PMID: 40817109 DOI: 10.1038/s41467-025-62765-z
Primary Citation of related structures
9HIU
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