9HHL image
Deposition Date 2024-11-21
Release Date 2025-12-03
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9HHL
Keywords:
MOTOR PROTEIN
Title:
Structure of Dynein-Dynactin-NuMA-LIS1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Sus scrofa (Taxon ID: 9823)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
6.53 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9HHL validation report
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nuclear mitotic apparatus pro
Gene (Uniprot):MGMT, NUMA1
Chain IDs:B (auth: 1), C (auth: 2)
Chain Length:889
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q14980,P16455 Pfam ID:PF21670, PF02870, PF01035 EC:2.1.1.63
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ARP1 actin related protein 1
Gene (Uniprot):ACTR1A
Chain IDs:D (auth: A), E (auth: B), F (auth: D), G (auth: E), H (auth: F), I (auth: G), K (auth: I), OA (auth: C)
Chain Length:376
Number of Molecules:8
Biological Source:Sus scrofa
UniProt ID:F2Z5G5 Pfam ID:PF00022
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Actin, cytoplasmic 1
Gene (Uniprot):ACTB
Chain IDs:J (auth: H)
Chain Length:375
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:Q6QAQ1 Pfam ID:PF00022
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Arp11
Gene (Uniprot):ACTR10
Chain IDs:L (auth: J)
Chain Length:417
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LHK5 Pfam ID:PF00022
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Capping protein (Actin filame
Gene (Uniprot):CAPZA1
Chain IDs:M (auth: K)
Chain Length:286
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0PFK5 Pfam ID:PF01267
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:F-actin-capping protein subun
Gene (Uniprot):CAPZB
Chain IDs:N (auth: L)
Chain Length:272
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0PFK7 Pfam ID:PF01115
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynactin subunit 2
Gene (Uniprot):DCTN2
Chain IDs:O (auth: M), P (auth: N), R (auth: P), S (auth: Q), V
Chain Length:405
Number of Molecules:5
Biological Source:Sus scrofa
UniProt ID:A0A5G2QD80 Pfam ID:PF04912
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynactin subunit 3
Gene (Uniprot):DCTN3
Chain IDs:Q (auth: O), T (auth: R)
Chain Length:612
Number of Molecules:2
Biological Source:Sus scrofa
UniProt ID:F1SEC0 Pfam ID:PF07426
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynactin subunit 1
Gene (Uniprot):DCTN1
Chain IDs:MA (auth: S), NA (auth: T)
Chain Length:1281
Number of Molecules:2
Biological Source:Sus scrofa
UniProt ID:A0A287B8J2 Pfam ID:PF01302, PF12455
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynactin 6
Gene (Uniprot):DCTN6
Chain IDs:U
Chain Length:492
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:D0G6S1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynactin subunit 5
Gene (Uniprot):DCTN5
Chain IDs:W
Chain Length:182
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZK88 Pfam ID:PF21711
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynactin subunit 4
Gene (Uniprot):DCTN4
Chain IDs:X (auth: Y)
Chain Length:467
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1TB62 Pfam ID:PF05502
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cytoplasmic dynein 1 heavy ch
Gene (Uniprot):DYNC1H1
Mutagens:R1567E, K1610E
Chain IDs:Y (auth: e), Z (auth: f), DA (auth: m), EA (auth: n)
Chain Length:4646
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q14204 Pfam ID:PF08385, PF08393, PF12774, PF17852, PF12775, PF22597, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cytoplasmic dynein 1 light in
Gene (Uniprot):DYNC1LI2
Chain IDs:CA (auth: j), GA (auth: q), JA (auth: u)
Chain Length:417
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:O43237 Pfam ID:PF05783
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cytoplasmic dynein 1 intermed
Gene (Uniprot):DYNC1I2
Chain IDs:A (auth: p), AA (auth: g), BA (auth: h), FA (auth: o)
Chain Length:612
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q13409 Pfam ID:PF11540, PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein light chain roadblock-
Gene (Uniprot):DYNLRB1
Chain IDs:HA (auth: s), IA (auth: t), KA (auth: w), LA (auth: z)
Chain Length:1281
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9NP97 Pfam ID:PF03259
Ligand Molecules
ADP
ATP
ZN
Primary Citation
Activation and regulation of the dynein-dynactin-NuMA complex.
Nat.Chem.Biol. ? ? ? (2026)
PMID: 41840068 DOI: 10.1038/s41589-026-02156-7
Primary Citation of related structures
9HHL
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