9HEO image
Deposition Date 2024-11-14
Release Date 2025-09-17
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9HEO
Keywords:
TRANSPORT PROTEIN
Title:
Open-state RyR1 in 0.05% POPC micelles, in complex with a nanobody and FKBP
Biological Source:
Source Organism(s):
Oryctolagus cuniculus (Taxon ID: 9986)
Lama glama (Taxon ID: 9844)
Expression System(s):
Oryctolagus cuniculus, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9HEO validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ryanodine receptor 1
Gene (Uniprot):RYR1
Chain IDs:A, C, G, J
Chain Length:5027
Number of Molecules:4
Biological Source:Oryctolagus cuniculus
UniProt ID:P11716 Pfam ID:PF08709, PF02815, PF01365, PF00622, PF02026, PF21119, PF08454, PF06459, PF00520
Polymer Type:polypeptide(L)
Molecule:Nanobody 9657
Chain IDs:B, D, H, K
Chain Length:126
Number of Molecules:4
Biological Source:Lama glama
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Peptidyl-prolyl cis-trans iso
Gene (Uniprot):FKBP1B
Chain IDs:E, F, I, L
Chain Length:107
Number of Molecules:4
Biological Source:Oryctolagus cuniculus
UniProt ID:Q8HYX6 Pfam ID:PF00254
Ligand Molecules
ATP
CA
CFF
POV
ZN
Primary Citation
Lipids modulate the open probability of RyR1 under cryo-EM conditions.
Structure 33 2029 2040.e3 (2025)
PMID: 41027431 DOI: 10.1016/j.str.2025.09.003
Primary Citation of related structures
9HEO
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