9GJQ image
Deposition Date 2024-08-22
Release Date 2025-09-03
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9GJQ
Keywords:
LIGASE
Title:
Crystal structure of humanised cereblon from Magnetospirillum gryphiswaldense bound by dihydrouracil-indole compound [1-(1H-indol-6-yl)dihydro-2,4(1H,3H)-pyrimidinedione].
Biological Source:
Source Organism(s):
Magnetospirillum gryphiswaldense (Taxon ID: 55518)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.39 Å
R-Value Free:
0.20
R-Value Work:
0.19
R-Value Observed:
0.20
Space Group:
C 2 2 21
9GJQ validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cereblon isoform 4
Gene (Uniprot):MGR_0879
Mutagens:A52H, M54Y, F56H, F77H, Y101F, R117A
Chain IDs:A
Chain Length:109
Number of Molecules:1
Biological Source:Magnetospirillum gryphiswaldense
UniProt ID:A4TVL0
Ligand Molecules
A1IMN
ZN
Primary Citation
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader.
Nat Commun ? ? ? (2026)
PMID: 41876537 DOI: 10.1038/s41467-026-70663-1
Primary Citation of related structures
9GJQ
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