ISDA: 9DW3

Deposition Date 2024-10-08

Release Date 2025-10-15

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9DW3

Keywords:

STRUCTURAL PROTEIN

Title:

Human mitochondrial ClpP in complex with Bortezomib

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.40 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):CLPP
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N
Chain Length:220
Number of Molecules:14
Biological Source:Homo sapiens

UniProt ID:Q16740 Pfam ID:PF00574 EC:3.4.21.92

Ligand Molecules

BO2

Primary Citation

Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation.

Chen, W, Lander, G.C, Yang, J.Show

Nat Commun 17 1064 1064 (2026)

PMID: 41593052 DOI: 10.1038/s41467-025-67010-1

Primary Citation of related structures

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