9CB1 image
Deposition Date 2024-06-18
Release Date 2025-05-28
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9CB1
Keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
Title:
Cryo-EM Structure of the Human Neutralizing Antibody 5-1 in Complex with Prefusion Human Metapneumovirus F Glycoprotein
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
human metapneumovirus (Taxon ID: 162145)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.24 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9CB1 validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:5-1 Fab Heavy Chain Variable
Chain IDs:A, B, C
Chain Length:219
Number of Molecules:3
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:5-1 Fab Light Chain Variable
Chain IDs:D, E, F
Chain Length:214
Number of Molecules:3
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fusion glycoprotein F0
Mutagens:multiple
Chain IDs:G, H, I
Chain Length:551
Number of Molecules:3
Biological Source:human metapneumovirus
UniProt ID:Q8B9P0
Ligand Molecules
NA
Primary Citation
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein.
Cell Rep Med 7 102564 102564 (2026)
PMID: 41547352 DOI: 10.1016/j.xcrm.2025.102564
Primary Citation of related structures
9CB1
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