ISDA: 8ZNY

Deposition Date 2024-05-28

Release Date 2025-06-04

Last Version Date 2026-04-08

Entry Detail

PDB ID:

8ZNY

Keywords:

CELL INVASION

Title:

Small GTPase RhoA Y42C mutant in complex with GDP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.65 Å

R-Value Free:

0.21

R-Value Work:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transforming protein RhoA
Gene (Uniprot):RHOA
Mutagens:Y42C
Chain IDs:A
Chain Length:182
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61586 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

GDP

Primary Citation

Discovering Targetable Conformation of RhoA Mutant by Integrating Native Mass Spectrometry, Ultraviolet Photodissociation, and X-ray Diffraction.

Wu, H, Liu, Z, Jiang, H, Zhao, H, Dong, C, Lu, Y, Zu, S, Guo, Y, Lai, C, Luo, P, Xu, K, Yang, Y, Yang, Y, Sun, Z, Huang, Q, Xiong, H, Zhou, L, Luo, Y, Zeng, Y, Du, D, Liang, Z, Xiao, W, Zhao, S, Zhang, W, Tang, Y, Xiao, C, Chen, K, Yang, X, Wang, F, Luo, C.Show

J.Am.Chem.Soc. 148 11709 11718 (2026)

PMID: 41837560 DOI: 10.1021/jacs.5c20067

Primary Citation of related structures

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