8YD2 image
Deposition Date 2024-02-19
Release Date 2025-03-19
Last Version Date 2026-04-01
Entry Detail
PDB ID:
8YD2
Keywords:
HYDROLASE
Title:
CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib
Biological Source:
Source Organism(s):
Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.39 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
8YD2 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP1
Chain IDs:A, C, E, G, I, K, M
Chain Length:178
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv
UniProt ID:P9WPC5 Pfam ID:PF00574 EC:3.4.21.92
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Chain IDs:B, D, F, H, J, L, N
Chain Length:180
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv
UniProt ID:P9WPC3 Pfam ID:PF00574 EC:3.4.21.92
Ligand Molecules
BO2
Primary Citation
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis
Nat Commun 16 3466 ? (2025)
DOI: 10.1038/s41467-025-58410-4
Primary Citation of related structures
8YD2
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