ISDA: 8YD1

Deposition Date 2024-02-19

Release Date 2025-03-19

Last Version Date 2026-04-01

Entry Detail

PDB ID:

8YD1

Keywords:

HYDROLASE

Title:

CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)
Bos grunniens (Taxon ID: 30521)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.81 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease AT
Gene (Uniprot):clpC1
Mutagens:E288A, F444S, E626A
Chain IDs:A, B, C, D, E, F
Chain Length:24
Number of Molecules:6
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC9 Pfam ID:PF00004, PF17871, PF07724, PF10431 EC:3.4.21.92

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Chain IDs:G, H, I, J, K, L, M
Chain Length:181
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC3 Pfam ID:PF00574 EC:3.4.21.92

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP1
Chain IDs:N, O, P, Q, R, S, T
Chain Length:178
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC5 Pfam ID:PF00574 EC:3.4.21.92

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-casein
Gene (Uniprot):CSN2
Chain IDs:U (auth: a)
Chain Length:24
Number of Molecules:1
Biological Source:Bos grunniens

UniProt ID:P02666

Ligand Molecules