ISDA: 8YD0

Deposition Date 2024-02-18

Release Date 2025-03-19

Last Version Date 2026-04-01

Entry Detail

PDB ID:

8YD0

Keywords:

HYDROLASE

Title:

CryoEM structure of M. tuberculosis ClpXP1P2 complex bound to bortezomib

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.24 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease AT
Gene (Uniprot):clpX
Mutagens:E187Q
Chain IDs:A, B, C, D, E, F
Chain Length:355
Number of Molecules:6
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPB9 Pfam ID:PF07724, PF10431

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Chain IDs:G (auth: H), H (auth: I), I (auth: K), J (auth: L), K (auth: M), L (auth: N), T (auth: V)
Chain Length:196
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC3 Pfam ID:PF00574 EC:3.4.21.92

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP1
Chain IDs:M (auth: O), N (auth: P), O (auth: Q), P (auth: R), Q (auth: S), R (auth: T), S (auth: U)
Chain Length:178
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC5 Pfam ID:PF00574 EC:3.4.21.92

Ligand Molecules