ISDA: 8VV1

Deposition Date 2024-01-30

Release Date 2025-03-19

Last Version Date 2026-04-01

Entry Detail

PDB ID:

8VV1

Keywords:

TRANSCRIPTION

Title:

Estrogen receptor alpha ligand binding domain in complex with palazestrant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.20

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Estrogen receptor
Gene (Uniprot):ESR1
Mutagens:C381S, C417S, C530S
Chain IDs:A, B
Chain Length:249
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P03372 Pfam ID:PF00104

Ligand Molecules

A1AEA

GOL

Primary Citation

Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD).

Ng, R.A, Barratt, S, Parisian, A, Palanisamy, G.S, Phukan, S, Sun, R, Robello, B, Pena, G, Sapugay, J, Yeghikyan, D, Wang, C, Satish Kher, S, Thangathirupathy, S, Millikin, R, Yu, G, Watanabe, T, Zhou, F, Rich, B, Duncan, A, Andersen, S.E, Chawla, R, Zak, D.R, Heerding, D.A, Hearn, B.R, Greene, G, Harmon, C.L, Hodges-Gallagher, L, Kushner, P.J, Fanning, S.W, Myles, D.C.Show

Acs Omega 10 22685 22700 (2025)

PMID: 40521471 DOI: 10.1021/acsomega.4c11023

Primary Citation of related structures

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