ISDA: 8TSK

Deposition Date 2023-08-11

Release Date 2025-06-11

Last Version Date 2026-03-04

Entry Detail

PDB ID:

8TSK

Keywords:

BIOSYNTHETIC PROTEIN

Title:

Structure of human LIAS in the presence of 5'-deoxyadenosine and octanoyl-modified peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.58 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lipoyl synthase, mitochondria
Gene (Uniprot):LIAS
Chain IDs:A, B
Chain Length:368
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O43766 Pfam ID:PF16881, PF04055

Ligand Molecules

5AD

LYS

MET

OCA

SF4

Primary Citation

Structural basis for catalysis by human lipoyl synthase.

Esakova, O.A, Warui, D.M, Neti, S.S, Alumasa, J.N, Booker, S.J.Show

Nat Commun 16 6355 6355 (2025)

PMID: 40640146 DOI: 10.1038/s41467-025-61393-x

Primary Citation of related structures

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