ISDA: 8KDZ

Deposition Date 2023-08-10

Release Date 2025-02-19

Last Version Date 2026-03-04

Entry Detail

PDB ID:

8KDZ

Keywords:

VIRAL PROTEIN

Title:

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-Adenosyl-L-homocysteine and Caffeic acid phenethyl ester

Biological Source:

Source Organism(s):

dengue virus type 3 (Taxon ID: 11069)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.27

R-Value Work:

0.23

Space Group:

P 2 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:methyltransferase
Chain IDs:A, B
Chain Length:284
Number of Molecules:2
Biological Source:dengue virus type 3

UniProt ID:A9LID6

Ligand Molecules

QAP

SAH

Primary Citation

Structure-based identification of herbacetin and caffeic acid phenethyl ester as inhibitors of S-adenosylmethionine-dependent viral methyltransferase.

Bhutkar, M, Kumar, A, Rani, R, Singh, V, Saha, A, Pathak, A, Kothiala, A, Mahajan, S, Waghmode, B, Verma, S, Kumar, R, Mudgal, R, Sircar, D, Kumar, P, Tomar, S.Show

Febs Lett. 599 1531 1555 (2025)

PMID: 40353321 DOI: 10.1002/1873-3468.70054

Primary Citation of related structures

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