8J07 image
Deposition Date 2023-04-09
Release Date 2023-07-26
Last Version Date 2025-09-17
Entry Detail
PDB ID:
8J07
Keywords:
STRUCTURAL PROTEIN
Title:
96nm repeat of human respiratory doublet microtubule and associated axonemal complexes
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.10 Å
Aggregation State:
FILAMENT
Reconstruction Method:
SINGLE PARTICLE
8J07 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex sub
Gene (Uniprot):GAS8
Chain IDs:A (auth: 0), ZB (auth: 4)
Chain Length:478
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:O95995 Pfam ID:PF13851
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex pro
Gene (Uniprot):DRC1
Chain IDs:B (auth: 1)
Chain Length:740
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96MC2 Pfam ID:PF14772, PF14775
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex pro
Gene (Uniprot):IQCD
Chain IDs:C (auth: 10)
Chain Length:449
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96DY2 Pfam ID:PF00612
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex pro
Gene (Uniprot):IQCA1
Chain IDs:D (auth: 11)
Chain Length:822
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q86XH1 Pfam ID:PF00004
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex pro
Gene (Uniprot):EFCAB2
Chain IDs:E (auth: 12), F (auth: 13), G (auth: 14), PE (auth: 8)
Chain Length:269
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q5VUJ9
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing fam
Gene (Uniprot):EFHB
Chain IDs:H (auth: 1A), I (auth: 1B), J (auth: 1C)
Chain Length:833
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q8N7U6 Pfam ID:PF13499, PF25325
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP45
Chain IDs:K (auth: 1D), L (auth: 1E), M (auth: 1F), N (auth: 1G), O (auth: 1H), P (auth: 1I), Q (auth: 1J)
Chain Length:551
Number of Molecules:7
Biological Source:Homo sapiens
UniProt ID:Q9UL16 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP52
Chain IDs:R (auth: 1L), S (auth: 1M), T (auth: 1N), U (auth: 1O), V (auth: 1P), W (auth: 1Q)
Chain Length:620
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:Q8N1V2 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP53
Chain IDs:X (auth: 1R), Y (auth: 1S), Z (auth: 1T)
Chain Length:514
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q96M91 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP95
Chain IDs:AA (auth: 1V), BA (auth: 1W)
Chain Length:229
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q5VTT2 Pfam ID:PF15139
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP107
Chain IDs:CA (auth: 1Y), DA (auth: 1Z)
Chain Length:194
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q8N1D5 Pfam ID:PF22595
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex sub
Gene (Uniprot):CCDC65
Chain IDs:EA (auth: 2)
Chain Length:484
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8IXS2 Pfam ID:PF14772
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein Flattop
Gene (Uniprot):CFAP126
Chain IDs:FA (auth: 2A), GA (auth: 2B), HA (auth: 2C), IA (auth: 2D), JA (auth: 2E), KA (auth: 2F), LA (auth: 2G)
Chain Length:177
Number of Molecules:7
Biological Source:Homo sapiens
UniProt ID:Q5VTH2 Pfam ID:PF22611
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP141
Chain IDs:MA (auth: 2I), NA (auth: 2J)
Chain Length:101
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q5VU69 Pfam ID:PF15104
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP161
Chain IDs:OA (auth: 2L), PA (auth: 2M), QA (auth: 2N), RA (auth: 2O)
Chain Length:301
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q6P656 Pfam ID:PF24569
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella- associat
Gene (Uniprot):CFAP210
Chain IDs:SA (auth: 2Q), TA (auth: 2R), UA (auth: 2S)
Chain Length:552
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q0VFZ6 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP276
Chain IDs:VA (auth: 2U), WA (auth: 2V), XA (auth: 2W), YA (auth: 2X), ZA (auth: 2Y), AB (auth: 2Z)
Chain Length:169
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:Q5T5A4 Pfam ID:PF12494
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex sub
Gene (Uniprot):DRC3
Chain IDs:BB (auth: 3)
Chain Length:523
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H069 Pfam ID:PF12799
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing pro
Gene (Uniprot):EFHC1
Chain IDs:CB (auth: 3A), DB (auth: 3B), EB (auth: 3C), FB (auth: 3D), GB (auth: 3E), HB (auth: 3F)
Chain Length:640
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:Q5JVL4 Pfam ID:PF06565
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing fam
Gene (Uniprot):EFHC2
Chain IDs:IB (auth: 3G), JB (auth: 3H), KB (auth: 3I), LB (auth: 3J), MB (auth: 3K), NB (auth: 3L), OB (auth: 3M)
Chain Length:749
Number of Molecules:7
Biological Source:Homo sapiens
UniProt ID:Q5JST6 Pfam ID:PF06565
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enkurin
Gene (Uniprot):ENKUR
Chain IDs:PB (auth: 3O), QB (auth: 3P), RB (auth: 3Q), SB (auth: 3R), TB (auth: 3S), UB (auth: 3T), VB (auth: 3U)
Chain Length:256
Number of Molecules:7
Biological Source:Homo sapiens
UniProt ID:Q8TC29 Pfam ID:PF13864
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Meiosis-specific nuclear stru
Gene (Uniprot):MNS1
Chain IDs:WB (auth: 3W), XB (auth: 3X), YB (auth: 3Y)
Chain Length:495
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q8NEH6 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein FAM166B
Gene (Uniprot):CIMIP2B
Chain IDs:AC (auth: 4A), BC (auth: 4B), CC (auth: 4C), DC (auth: 4D), EC (auth: 4E), FC (auth: 4F), GC (auth: 4G), HC (auth: 4H), IC (auth: 4I), JC (auth: 4J), KC (auth: 4K), LC (auth: 4L), MC (auth: 4M)
Chain Length:275
Number of Molecules:13
Biological Source:Homo sapiens
UniProt ID:A8MTA8 Pfam ID:PF10629
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nucleoside diphosphate kinase
Gene (Uniprot):NME7
Chain IDs:NC (auth: 4O), OC (auth: 4P), PC (auth: 4Q), QC (auth: 4R)
Chain Length:376
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9Y5B8 Pfam ID:PF00334, PF25364
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Piercer of microtubule wall 1
Gene (Uniprot):PIERCE1
Chain IDs:RC (auth: 4S), SC (auth: 4T)
Chain Length:136
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q5BN46 Pfam ID:PF14892
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Piercer of microtubule wall 2
Gene (Uniprot):PIERCE2
Chain IDs:TC (auth: 4U), UC (auth: 4V), VC (auth: 4W)
Chain Length:121
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:H3BRN8 Pfam ID:PF14892
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex sub
Gene (Uniprot):TCTE1
Chain IDs:WC (auth: 5)
Chain Length:501
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q5JU00 Pfam ID:PF13516
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RIB43A-like with coiled-coils
Gene (Uniprot):RIBC2
Chain IDs:XC (auth: 5A), YC (auth: 5B), ZC (auth: 5C)
Chain Length:382
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q9H4K1 Pfam ID:PF05914
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RIB43A-like with coiled-coils
Gene (Uniprot):RIBC1
Chain IDs:AD (auth: 5D), BD (auth: 5E), CD (auth: 5F)
Chain Length:379
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q8N443 Pfam ID:PF05914
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sperm-associated antigen 8
Gene (Uniprot):SPAG8
Chain IDs:DD (auth: 5H), ED (auth: 5I), FD (auth: 5J)
Chain Length:485
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q99932 Pfam ID:PF22584
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein CFAP6
Gene (Uniprot):CFAP68
Chain IDs:GD (auth: 5L), HD (auth: 5M)
Chain Length:150
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9H5F2 Pfam ID:PF06608
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP77
Chain IDs:ID (auth: 5O), JD (auth: 5P), KD (auth: 5Q), LD (auth: 5R), MD (auth: 5S), ND (auth: 5T), OD (auth: 5U), PD (auth: 5V)
Chain Length:284
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q6ZQR2 Pfam ID:PF14825
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein CFAP9
Gene (Uniprot):CFAP90
Chain IDs:QD (auth: 5X), RD (auth: 5Y)
Chain Length:147
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:A4QMS7 Pfam ID:PF15074
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sperm acrosome-associated pro
Gene (Uniprot):SPACA9
Chain IDs:SD (auth: 6A), TD (auth: 6C), UD (auth: 6E), VD (auth: 6G), WD (auth: 6I), XD (auth: 6K), YD (auth: 6L), ZD (auth: 6N), AE (auth: 6O), BE (auth: 6Q), CE (auth: 6R), DE (auth: 6T), EE (auth: 6V)
Chain Length:222
Number of Molecules:13
Biological Source:Homo sapiens
UniProt ID:Q96E40 Pfam ID:PF15120
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex sub
Gene (Uniprot):DRC7
Chain IDs:FE (auth: 7)
Chain Length:874
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8IY82 Pfam ID:PF24656, PF24667, PF24671
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein FAM166C
Gene (Uniprot):CIMIP2C
Chain IDs:GE (auth: 7A), HE (auth: 7B), IE (auth: 7C), JE (auth: 7D), KE (auth: 7E), LE (auth: 7F), ME (auth: 7G)
Chain Length:201
Number of Molecules:7
Biological Source:Homo sapiens
UniProt ID:A6NJV1 Pfam ID:PF10629
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP144
Chain IDs:NE (auth: 7I), OE (auth: 7J)
Chain Length:134
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:A6NL82 Pfam ID:PF14886
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-1
Gene (Uniprot):TEKT1
Chain IDs:QE (auth: 8A), RE (auth: 8B), SE (auth: 8C), TE (auth: 8D), UE (auth: 8E), VE (auth: 8F), WE (auth: 8G), XE (auth: 8H)
Chain Length:418
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q969V4 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-2
Gene (Uniprot):TEKT2
Chain IDs:YE (auth: 8J), ZE (auth: 8K), AF (auth: 8L), BF (auth: 8M), CF (auth: 8N), DF (auth: 8O), EF (auth: 8P), FF (auth: 8Q)
Chain Length:430
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q9UIF3 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein regulatory complex pro
Gene (Uniprot):DRC9
Chain IDs:GF (auth: 9)
Chain Length:443
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H095 Pfam ID:PF00612
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Radial spoke head 1 homolog
Gene (Uniprot):RSPH1
Chain IDs:HF (auth: A), HG (auth: B), HH (auth: C), HI (auth: D), HDA (auth: a), SDA (auth: b), DEA (auth: c), LEA (auth: d)
Chain Length:309
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q8WYR4 Pfam ID:PF02493
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin beta-4B chain
Gene (Uniprot):TUBB4B
Chain IDs:JF (auth: AB), LF (auth: AD), NF (auth: AF), PF (auth: AH), RF (auth: AJ), TF (auth: AL), VF (auth: AN), XF (auth: AP), ZF (auth: AR), BG (auth: AT), DG (auth: AV), FG (auth: AX), JG (auth: BB), LG (auth: BD), NG (auth: BF), PG (auth: BH), RG (auth: BJ), TG (auth: BL), VG (auth: BN), XG (auth: BP), ZG (auth: BR), BH (auth: BT), DH (auth: BV), FH (auth: BX), IH (auth: CB), KH (auth: CD), MH (auth: CF), OH (auth: CH), QH (auth: CJ), SH (auth: CL), UH (auth: CN), WH (auth: CP), YH (auth: CR), AI (auth: CT), CI (auth: CV), EI (auth: CX), GI (auth: CZ), II (auth: DB), KI (auth: DD), MI (auth: DF), OI (auth: DH), QI (auth: DJ), SI (auth: DL), UI (auth: DN), WI (auth: DP), YI (auth: DR), AJ (auth: DT), CJ (auth: DV), EJ (auth: DX), GJ (auth: DZ), IJ (auth: EB), KJ (auth: ED), MJ (auth: EF), OJ (auth: EH), QJ (auth: EJ), SJ (auth: EL), UJ (auth: EN), WJ (auth: EP), YJ (auth: ER), AK (auth: ET), CK (auth: EV), EK (auth: EX), GK (auth: EZ), IK (auth: FB), KK (auth: FD), MK (auth: FF), OK (auth: FH), QK (auth: FJ), SK (auth: FL), UK (auth: FN), WK (auth: FP), YK (auth: FR), AL (auth: FT), CL (auth: FV), EL (auth: FX), GL (auth: FZ), IL (auth: GB), KL (auth: GD), ML (auth: GF), OL (auth: GH), QL (auth: GJ), SL (auth: GL), UL (auth: GN), WL (auth: GP), YL (auth: GR), AM (auth: GT), CM (auth: GV), EM (auth: GX), GM (auth: GZ), JM (auth: HB), LM (auth: HD), NM (auth: HF), PM (auth: HH), RM (auth: HJ), TM (auth: HL), VM (auth: HN), XM (auth: HP), ZM (auth: HR), BN (auth: HT), DN (auth: HV), FN (auth: HX), HN (auth: HZ), KN (auth: IB), MN (auth: ID), ON (auth: IF), QN (auth: IH), SN (auth: IJ), UN (auth: IL), WN (auth: IN), YN (auth: IP), AO (auth: IR), CO (auth: IT), EO (auth: IV), GO (auth: IX), JO (auth: JB), LO (auth: JD), NO (auth: JF), PO (auth: JH), RO (auth: JJ), TO (auth: JL), VO (auth: JN), XO (auth: JP), ZO (auth: JR), BP (auth: JT), DP (auth: JV), FP (auth: JX), HP (auth: JZ), JP (auth: KB), LP (auth: KD), NP (auth: KF), PP (auth: KH), RP (auth: KJ), TP (auth: KL), VP (auth: KN), XP (auth: KP), ZP (auth: KR), BQ (auth: KT), DQ (auth: KV), FQ (auth: KX), HQ (auth: KZ), JQ (auth: LB), LQ (auth: LD), NQ (auth: LF), PQ (auth: LH), RQ (auth: LJ), TQ (auth: LL), VQ (auth: LN), XQ (auth: LP), ZQ (auth: LR), BR (auth: LT), DR (auth: LV), FR (auth: LX), HR (auth: LZ), LR (auth: MD), NR (auth: MF), PR (auth: MH), RR (auth: MJ), TR (auth: ML), VR (auth: MN), XR (auth: MP), ZR (auth: MR), BS (auth: MT), DS (auth: MV), FS (auth: MX), HS (auth: MZ), KS (auth: NB), MS (auth: ND), OS (auth: NF), QS (auth: NH), SS (auth: NJ), US (auth: NL), WS (auth: NN), YS (auth: NP), AT (auth: NR), CT (auth: NT), ET (auth: NV), GT (auth: NX), HT (auth: NZ), KT (auth: OB), MT (auth: OD), OT (auth: OF), QT (auth: OH), ST (auth: OJ), UT (auth: OL), WT (auth: ON), YT (auth: OP), AU (auth: OR), CU (auth: OT), EU (auth: OV), GU (auth: OX), KU (auth: PB), MU (auth: PD), OU (auth: PF), QU (auth: PH), SU (auth: PJ), UU (auth: PL), WU (auth: PN), YU (auth: PP), AV (auth: PR), CV (auth: PT), EV (auth: PV), GV (auth: PX), KV (auth: QB), MV (auth: QD), OV (auth: QF), QV (auth: QH), SV (auth: QJ), UV (auth: QL), WV (auth: QN), YV (auth: QP), AW (auth: QR), CW (auth: QT), EW (auth: QV), GW (auth: QX), KW (auth: RB), MW (auth: RD), OW (auth: RF), QW (auth: RH), SW (auth: RJ), UW (auth: RL), WW (auth: RN), YW (auth: RP), AX (auth: RR), CX (auth: RT), EX (auth: RV), GX (auth: RX), JX (auth: SB), LX (auth: SD), NX (auth: SF), PX (auth: SH), RX (auth: SJ), TX (auth: SL), VX (auth: SN), XX (auth: SP), ZX (auth: SR), BY (auth: ST), DY (auth: SV), FY (auth: SX), IY (auth: TB), KY (auth: TD), MY (auth: TF), OY (auth: TH), QY (auth: TJ), SY (auth: TL), UY (auth: TN), WY (auth: TP), YY (auth: TR), AZ (auth: TT), CZ (auth: TV), EZ (auth: TX), GZ (auth: TZ), IZ (auth: UB), KZ (auth: UD), MZ (auth: UF), OZ (auth: UH), QZ (auth: UJ), SZ (auth: UL), UZ (auth: UN), WZ (auth: UP), YZ (auth: UR), AAA (auth: UT), CAA (auth: UV), EAA (auth: UX), GAA (auth: UZ), IAA (auth: VB), KAA (auth: VD), MAA (auth: VF), OAA (auth: VH), QAA (auth: VJ), SAA (auth: VL), UAA (auth: VN), WAA (auth: VP), YAA (auth: VR), ABA (auth: VT), CBA (auth: VV), EBA (auth: VX), GBA (auth: VZ), JBA (auth: WB), LBA (auth: WD), NBA (auth: WF), PBA (auth: WH), RBA (auth: WJ), TBA (auth: WL), VBA (auth: WN), XBA (auth: WP), ZBA (auth: WR), BCA (auth: WT), DCA (auth: WV), FCA (auth: WX)
Chain Length:445
Number of Molecules:289
Biological Source:Homo sapiens
UniProt ID:P68371 Pfam ID:PF00091, PF03953
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin alpha-1A chain
Gene (Uniprot):TUBA1A
Chain IDs:IF (auth: AZ), KF (auth: AC), MF (auth: AE), OF (auth: AG), QF (auth: AI), SF (auth: AK), UF (auth: AM), WF (auth: AO), YF (auth: AQ), AG (auth: AS), CG (auth: AU), EG (auth: AW), GG (auth: AY), IG (auth: BA), KG (auth: BC), MG (auth: BE), OG (auth: BG), QG (auth: BI), SG (auth: BK), UG (auth: BM), WG (auth: BO), YG (auth: BQ), AH (auth: BS), CH (auth: BU), EH (auth: BW), GH (auth: BY), JH (auth: CC), LH (auth: CE), NH (auth: CG), PH (auth: CI), RH (auth: CK), TH (auth: CM), VH (auth: CO), XH (auth: CQ), ZH (auth: CS), BI (auth: CU), DI (auth: CW), FI (auth: CY), JI (auth: DC), LI (auth: DE), NI (auth: DG), PI (auth: DI), RI (auth: DK), TI (auth: DM), VI (auth: DO), XI (auth: DQ), ZI (auth: DS), BJ (auth: DU), DJ (auth: DW), FJ (auth: DY), JJ (auth: EC), LJ (auth: EE), NJ (auth: EG), PJ (auth: EI), RJ (auth: EK), TJ (auth: EM), VJ (auth: EO), XJ (auth: EQ), ZJ (auth: ES), BK (auth: EU), DK (auth: EW), FK (auth: EY), JK (auth: FC), LK (auth: FE), NK (auth: FG), PK (auth: FI), RK (auth: FK), TK (auth: FM), VK (auth: FO), XK (auth: FQ), ZK (auth: FS), BL (auth: FU), DL (auth: FW), FL (auth: FY), JL (auth: GC), LL (auth: GE), NL (auth: GG), PL (auth: GI), RL (auth: GK), TL (auth: GM), VL (auth: GO), XL (auth: GQ), ZL (auth: GS), BM (auth: GU), DM (auth: GW), FM (auth: GY), IM (auth: HA), KM (auth: HC), MM (auth: HE), OM (auth: HG), QM (auth: HI), SM (auth: HK), UM (auth: HM), WM (auth: HO), YM (auth: HQ), AN (auth: HS), CN (auth: HU), EN (auth: HW), GN (auth: HY), JN (auth: IA), LN (auth: IC), NN (auth: IE), PN (auth: IG), RN (auth: II), TN (auth: IK), VN (auth: IM), XN (auth: IO), ZN (auth: IQ), BO (auth: IS), DO (auth: IU), FO (auth: IW), HO (auth: IY), KO (auth: JC), MO (auth: JE), OO (auth: JG), QO (auth: JI), SO (auth: JK), UO (auth: JM), WO (auth: JO), YO (auth: JQ), AP (auth: JS), CP (auth: JU), EP (auth: JW), GP (auth: JY), KP (auth: KC), MP (auth: KE), OP (auth: KG), QP (auth: KI), SP (auth: KK), UP (auth: KM), WP (auth: KO), YP (auth: KQ), AQ (auth: KS), CQ (auth: KU), EQ (auth: KW), GQ (auth: KY), KQ (auth: LC), MQ (auth: LE), OQ (auth: LG), QQ (auth: LI), SQ (auth: LK), UQ (auth: LM), WQ (auth: LO), YQ (auth: LQ), AR (auth: LS), CR (auth: LU), ER (auth: LW), GR (auth: LY), JR (auth: MA), KR (auth: MC), MR (auth: ME), OR (auth: MG), QR (auth: MI), SR (auth: MK), UR (auth: MM), WR (auth: MO), YR (auth: MQ), AS (auth: MS), CS (auth: MU), ES (auth: MW), GS (auth: MY), JS (auth: NA), LS (auth: NC), NS (auth: NE), PS (auth: NG), RS (auth: NI), TS (auth: NK), VS (auth: NM), XS (auth: NO), ZS (auth: NQ), BT (auth: NS), DT (auth: NU), FT (auth: NW), JT (auth: OA), LT (auth: OC), NT (auth: OE), PT (auth: OG), RT (auth: OI), TT (auth: OK), VT (auth: OM), XT (auth: OO), ZT (auth: OQ), BU (auth: OS), DU (auth: OU), FU (auth: OW), HU (auth: OY), JU (auth: PA), LU (auth: PC), NU (auth: PE), PU (auth: PG), RU (auth: PI), TU (auth: PK), VU (auth: PM), XU (auth: PO), ZU (auth: PQ), BV (auth: PS), DV (auth: PU), FV (auth: PW), HV (auth: PY), JV (auth: QA), LV (auth: QC), NV (auth: QE), PV (auth: QG), RV (auth: QI), TV (auth: QK), VV (auth: QM), XV (auth: QO), ZV (auth: QQ), BW (auth: QS), DW (auth: QU), FW (auth: QW), HW (auth: QY), JW (auth: RA), LW (auth: RC), NW (auth: RE), PW (auth: RG), RW (auth: RI), TW (auth: RK), VW (auth: RM), XW (auth: RO), ZW (auth: RQ), BX (auth: RS), DX (auth: RU), FX (auth: RW), HX (auth: RY), KX (auth: SC), MX (auth: SE), OX (auth: SG), QX (auth: SI), SX (auth: SK), UX (auth: SM), WX (auth: SO), YX (auth: SQ), AY (auth: SS), CY (auth: SU), EY (auth: SW), GY (auth: SY), JY (auth: TC), LY (auth: TE), NY (auth: TG), PY (auth: TI), RY (auth: TK), TY (auth: TM), VY (auth: TO), XY (auth: TQ), ZY (auth: TS), BZ (auth: TU), DZ (auth: TW), FZ (auth: TY), JZ (auth: UC), LZ (auth: UE), NZ (auth: UG), PZ (auth: UI), RZ (auth: UK), TZ (auth: UM), VZ (auth: UO), XZ (auth: UQ), ZZ (auth: US), BAA (auth: UU), DAA (auth: UW), FAA (auth: UY), JAA (auth: VC), LAA (auth: VE), NAA (auth: VG), PAA (auth: VI), RAA (auth: VK), TAA (auth: VM), VAA (auth: VO), XAA (auth: VQ), ZAA (auth: VS), BBA (auth: VU), DBA (auth: VW), FBA (auth: VY), IBA (auth: WA), KBA (auth: WC), MBA (auth: WE), OBA (auth: WG), QBA (auth: WI), SBA (auth: WK), UBA (auth: WM), WBA (auth: WO), YBA (auth: WQ), ACA (auth: WS), CCA (auth: WU), ECA (auth: WW)
Chain Length:451
Number of Molecules:285
Biological Source:Homo sapiens
UniProt ID:Q71U36 Pfam ID:PF00091, PF03953
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Radial spoke head protein 3 h
Gene (Uniprot):RSPH3
Chain IDs:HJ (auth: E), HK (auth: F), WEA (auth: e), HFA (auth: f)
Chain Length:560
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q86UC2 Pfam ID:PF06098
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Radial spoke head protein 4 h
Gene (Uniprot):RSPH4A
Chain IDs:HL (auth: G), HM (auth: H), IN (auth: I), IO (auth: J), KFA (auth: g), RFA (auth: h), WFA (auth: i), GGA (auth: j)
Chain Length:716
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q5TD94 Pfam ID:PF04712
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sperm surface protein Sp17
Gene (Uniprot):SPA17
Chain IDs:IP (auth: K), IQ (auth: L), LGA (auth: k), TGA (auth: l)
Chain Length:151
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q15506 Pfam ID:PF02197, PF00612
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Radial spoke head protein 9 h
Gene (Uniprot):RSPH9
Chain IDs:IR (auth: M), IS (auth: N), IT (auth: O), IU (auth: P), CHA (auth: m), NHA (auth: n), YHA (auth: o), GIA (auth: p)
Chain Length:276
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q9H1X1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ropporin-1-like protein
Gene (Uniprot):ROPN1L
Chain IDs:IV (auth: Q), IW (auth: R), RIA (auth: q), CJA (auth: r)
Chain Length:230
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q96C74
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Probable inactive peptidyl-pr
Gene (Uniprot):PPIL6
Chain IDs:IX (auth: S), NJA (auth: s)
Chain Length:311
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q8IXY8 Pfam ID:PF00160
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Radial spoke head 14 homolog
Gene (Uniprot):RSPH14
Chain IDs:HY (auth: T), VJA (auth: t)
Chain Length:348
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9UHP6 Pfam ID:PF00514
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DnaJ homolog subfamily B memb
Gene (Uniprot):DNAJB13
Chain IDs:HZ (auth: U), HAA (auth: V), YJA (auth: u), EKA (auth: v)
Chain Length:316
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P59910 Pfam ID:PF00226, PF01556
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Calmodulin-1
Gene (Uniprot):CALM1
Chain IDs:HBA (auth: W)
Chain Length:464
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P0DP23 Pfam ID:PF13499
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nucleoside diphosphate kinase
Gene (Uniprot):NME5
Chain IDs:GCA (auth: X), UCA (auth: Y), JKA (auth: x), KKA (auth: y)
Chain Length:212
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P56597 Pfam ID:PF00334, PF05186
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP20
Chain IDs:HCA (auth: XA), ICA (auth: XB), JCA (auth: XC), KCA (auth: XD), LCA (auth: XE), MCA (auth: XF), NCA (auth: XG), OCA (auth: XH), PCA (auth: XI), QCA (auth: XJ), RCA (auth: XK), SCA (auth: XL), TCA (auth: XM)
Chain Length:193
Number of Molecules:13
Biological Source:Homo sapiens
UniProt ID:Q9Y6A4 Pfam ID:PF05018
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Parkin coregulated gene prote
Gene (Uniprot):PACRG
Chain IDs:VCA (auth: YB), WCA (auth: YC), XCA (auth: YD), YCA (auth: YF), ZCA (auth: YG), ADA (auth: YH), BDA (auth: YI), CDA (auth: YJ), DDA (auth: YK), EDA (auth: YL), FDA (auth: YM)
Chain Length:257
Number of Molecules:11
Biological Source:Homo sapiens
UniProt ID:Q96M98 Pfam ID:PF10274
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cytochrome b5 domain-containi
Gene (Uniprot):CYB5D1
Chain IDs:GDA (auth: Z), LKA (auth: z)
Chain Length:228
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q6P9G0 Pfam ID:PF00173
Polymer Type:polypeptide(L)
Molecule:Unknown
Chain IDs:IDA (auth: a0)
Chain Length:72
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:DYNLL1
Chain IDs:JDA (auth: a1), KDA (auth: a2), LDA (auth: a3), MDA (auth: a4), NDA (auth: a5), ODA (auth: a6), PDA (auth: a7), QDA (auth: a8), RDA (auth: a9), TDA (auth: b0), UDA (auth: b1), VDA (auth: b2), WDA (auth: b3), XDA (auth: b4), YDA (auth: b5), ZDA (auth: b6), AEA (auth: b7), BEA (auth: b8), CEA (auth: b9), EEA (auth: c0), UGA (auth: l1), VGA (auth: l2), WGA (auth: l3), XGA (auth: l4), YGA (auth: l5), ZGA (auth: l6), PHA (auth: n1), QHA (auth: n2), RHA (auth: n3), SHA (auth: n4), THA (auth: n5), UHA (auth: n6), IIA (auth: p1), JIA (auth: p2), KIA (auth: p3), LIA (auth: p4), MIA (auth: p5), NIA (auth: p6), EJA (auth: r1), FJA (auth: r2), GJA (auth: r3), HJA (auth: r4), IJA (auth: r5), JJA (auth: r6)
Chain Length:89
Number of Molecules:44
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:MORN repeat-containing protei
Gene (Uniprot):MORN3
Chain IDs:FEA (auth: c1)
Chain Length:240
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6PF18 Pfam ID:PF02493
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:IQ and ubiquitin-like domain-
Gene (Uniprot):IQUB
Chain IDs:GEA (auth: c2)
Chain Length:791
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8NA54 Pfam ID:PF00240, PF25805
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DPY30 domain-containing prote
Gene (Uniprot):DYDC2
Chain IDs:HEA (auth: c3), IEA (auth: c4), JEA (auth: c5), KEA (auth: c6)
Chain Length:177
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q96IM9 Pfam ID:PF05186
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP61
Chain IDs:MEA (auth: d0)
Chain Length:1237
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8NHU2 Pfam ID:PF16092, PF23150
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP91
Chain IDs:NEA (auth: d1)
Chain Length:767
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7Z4T9 Pfam ID:PF14738
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP251
Chain IDs:OEA (auth: d2)
Chain Length:1149
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8TBY9 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tetratricopeptide repeat prot
Gene (Uniprot):TTC29
Chain IDs:PEA (auth: d3)
Chain Length:475
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8NA56 Pfam ID:PF13432, PF13424
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Zinc finger MYND domain-conta
Gene (Uniprot):ZMYND12
Chain IDs:QEA (auth: d4)
Chain Length:365
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H0C1 Pfam ID:PF01753
Polymer Type:polypeptide(L)
Molecule:ACTA2
Chain IDs:REA (auth: d5), SEA (auth: d6), TEA (auth: d7), UEA (auth: d8), VEA (auth: d9), IFA (auth: f1)
Chain Length:377
Number of Molecules:6
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Axonemal dynein light interme
Gene (Uniprot):DNALI1
Chain IDs:XEA (auth: e0), YEA (auth: e1), ZEA (auth: e2), AFA (auth: e3), BFA (auth: e4), CFA (auth: e5), DFA (auth: e6), EFA (auth: e7), FFA (auth: e8), GFA (auth: e9)
Chain Length:258
Number of Molecules:10
Biological Source:Homo sapiens
UniProt ID:O14645 Pfam ID:PF10211
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Centrin-2
Gene (Uniprot):CETN2
Chain IDs:JFA (auth: f2)
Chain Length:172
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P41208 Pfam ID:PF13499
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 1
Gene (Uniprot):DNAH12
Chain IDs:LFA (auth: g1)
Chain Length:3960
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:E9PG32 Pfam ID:PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 7
Gene (Uniprot):DNAH7
Chain IDs:MFA (auth: g2), OFA (auth: g4)
Chain Length:4024
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q8WXX0 Pfam ID:PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 3
Gene (Uniprot):DNAH3
Chain IDs:NFA (auth: g3)
Chain Length:4116
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8TD57 Pfam ID:PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 6
Gene (Uniprot):DNAH6
Chain IDs:PFA (auth: g5)
Chain Length:4158
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9C0G6 Pfam ID:PF08393, PF12774, PF03028, PF18198, PF18199, PF12781, PF17852, PF12775, PF17857, PF12780, PF12777
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 1
Gene (Uniprot):DNAH1
Chain IDs:QFA (auth: g6)
Chain Length:4265
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P2D7 Pfam ID:PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil domain-containing
Gene (Uniprot):CCDC39
Chain IDs:SFA (auth: h1), TFA (auth: h2)
Chain Length:941
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9UFE4 Pfam ID:PF24161
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil domain-containing
Gene (Uniprot):CCDC40
Chain IDs:UFA (auth: h3), VFA (auth: h4)
Chain Length:1142
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q4G0X9 Pfam ID:PF08647
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil domain-containing
Gene (Uniprot):CFAP184
Chain IDs:XFA (auth: i1)
Chain Length:555
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q2M329 Pfam ID:PF13870
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil domain-containing
Gene (Uniprot):CFAP263
Chain IDs:YFA (auth: i2)
Chain Length:377
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9H0I3 Pfam ID:PF13870
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP299
Chain IDs:ZFA (auth: i3)
Chain Length:233
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6V702 Pfam ID:PF14713
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP57
Chain IDs:AGA (auth: i4), BGA (auth: i5)
Chain Length:1250
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q96MR6 Pfam ID:PF00400, PF23414
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP43
Chain IDs:CGA (auth: i6), EGA (auth: i8)
Chain Length:1665
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q8NDM7 Pfam ID:PF25828
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP44
Chain IDs:DGA (auth: i7), FGA (auth: i9)
Chain Length:1854
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q96MT7 Pfam ID:PF00400, PF23409
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP58
Chain IDs:HGA (auth: j1), IGA (auth: j2)
Chain Length:872
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q5T655 Pfam ID:PF21771
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP73
Chain IDs:JGA (auth: j3)
Chain Length:308
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A6NFT4 Pfam ID:PF13863
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP100
Chain IDs:KGA (auth: j4)
Chain Length:611
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q494V2 Pfam ID:PF13863
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal intermediate
Gene (Uniprot):DNAI3
Chain IDs:MGA (auth: k1)
Chain Length:891
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8IWG1
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal intermediate
Gene (Uniprot):DNAI4
Chain IDs:NGA (auth: k2)
Chain Length:848
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q5VTH9 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal intermediate
Gene (Uniprot):DNAI7
Chain IDs:OGA (auth: k3)
Chain Length:716
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6TDU7 Pfam ID:PF15927, PF12366
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein light chain roadblock-
Gene (Uniprot):DYNLRB1
Chain IDs:PGA (auth: k4), HHA (auth: m4), CIA (auth: o4), WIA (auth: q4)
Chain Length:96
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9NP97 Pfam ID:PF03259
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein light chain roadblock-
Gene (Uniprot):DYNLRB2
Chain IDs:QGA (auth: k5), IHA (auth: m5), DIA (auth: o5), XIA (auth: q5)
Chain Length:96
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q8TF09 Pfam ID:PF03259
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 1
Gene (Uniprot):DNAH10
Chain IDs:RGA (auth: k8)
Chain Length:4589
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A0A669KB38 Pfam ID:PF08385, PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 2
Gene (Uniprot):DNAH2
Chain IDs:SGA (auth: k9)
Chain Length:4427
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P225 Pfam ID:PF08385, PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199, PF25007
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein light chain Tctex-type
Gene (Uniprot):DYNLT2B
Chain IDs:AHA (auth: l7), VHA (auth: n7), OIA (auth: p7), KJA (auth: r7)
Chain Length:142
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q8WW35 Pfam ID:PF03645
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein light chain Tctex-type
Gene (Uniprot):DYNLT1
Chain IDs:BHA (auth: l8), WHA (auth: n8), PIA (auth: p8), LJA (auth: r8)
Chain Length:113
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P63172 Pfam ID:PF03645
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Calaxin
Gene (Uniprot):CLXN
Chain IDs:DHA (auth: m0), SIA (auth: q0), OJA (auth: s0), ZJA (auth: u0)
Chain Length:211
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9HAE3 Pfam ID:PF13499
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal intermediate
Gene (Uniprot):DNAI1
Chain IDs:EHA (auth: m1), ZHA (auth: o1), TIA (auth: q1), PJA (auth: s1)
Chain Length:699
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9UI46 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal intermediate
Gene (Uniprot):DNAI2
Chain IDs:FHA (auth: m2), AIA (auth: o2), UIA (auth: q2), QJA (auth: s2)
Chain Length:605
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9GZS0 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal light chain 1
Gene (Uniprot):DNAL1
Chain IDs:GHA (auth: m3), BIA (auth: o3), VIA (auth: q3)
Chain Length:190
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q4LDG9 Pfam ID:PF12799
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dynein arm-docking comp
Gene (Uniprot):ODAD1
Chain IDs:JHA (auth: m6), EIA (auth: o6), YIA (auth: q6), RJA (auth: s6), AKA (auth: u6)
Chain Length:670
Number of Molecules:5
Biological Source:Homo sapiens
UniProt ID:Q96M63 Pfam ID:PF21773
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dynein arm-docking comp
Gene (Uniprot):ODAD2
Chain IDs:KHA (auth: m7), ZIA (auth: q7), SJA (auth: s7), BKA (auth: u7)
Chain Length:1044
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q5T2S8 Pfam ID:PF00514
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dynein arm-docking comp
Gene (Uniprot):ODAD3
Chain IDs:LHA (auth: m8), FIA (auth: o8), AJA (auth: q8), TJA (auth: s8), CKA (auth: u8)
Chain Length:595
Number of Molecules:5
Biological Source:Homo sapiens
UniProt ID:A5D8V7
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dynein arm-docking comp
Gene (Uniprot):ODAD4
Chain IDs:MHA (auth: m9), BJA (auth: q9), UJA (auth: s9), DKA (auth: u9)
Chain Length:672
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q96NG3 Pfam ID:PF13181
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 5
Gene (Uniprot):DNAH5
Chain IDs:OHA (auth: n0), HIA (auth: p0), DJA (auth: r0), WJA (auth: t0)
Chain Length:4624
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q8TE73 Pfam ID:PF08385, PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199, PF25007
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dynein axonemal heavy chain 9
Gene (Uniprot):DNAH9
Chain IDs:XHA (auth: n9), QIA (auth: p9), MJA (auth: r9), XJA (auth: t9)
Chain Length:4486
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9NYC9 Pfam ID:PF08385, PF08393, PF12774, PF17852, PF12775, PF17857, PF12780, PF12777, PF12781, PF03028, PF18198, PF18199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Thioredoxin domain-containing
Gene (Uniprot):NME9
Chain IDs:FKA (auth: v1), GKA (auth: v2), HKA (auth: v3)
Chain Length:330
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:Q86XW9 Pfam ID:PF00085, PF00334
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat-containin
Gene (Uniprot):LRRC34
Chain IDs:IKA (auth: w)
Chain Length:464
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8IZ02 Pfam ID:PF13516
Ligand Molecules
GDP
GTP
MG
Primary Citation
Axonemal structures reveal mechanoregulatory and disease mechanisms.
Nature 618 625 633 (2023)
PMID: 37258679 DOI: 10.1038/s41586-023-06140-2

Abstact

Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid and to enable spermatozoa and unicellular eukaryotes to swim. In humans, defective ciliary motility can lead to male infertility and a congenital disorder called primary ciliary dyskinesia (PCD), in which impaired clearance of mucus by the cilia causes chronic respiratory infections1. Ciliary movement is generated by the axoneme, a molecular machine consisting of microtubules, ATP-powered dynein motors and regulatory complexes2. The size and complexity of the axoneme has so far prevented the development of an atomic model, hindering efforts to understand how it functions. Here we capitalize on recent developments in artificial intelligence-enabled structure prediction and cryo-electron microscopy (cryo-EM) to determine the structure of the 96-nm modular repeats of axonemes from the flagella of the alga Chlamydomonas reinhardtii and human respiratory cilia. Our atomic models provide insights into the conservation and specialization of axonemes, the interconnectivity between dyneins and their regulators, and the mechanisms that maintain axonemal periodicity. Correlated conformational changes in mechanoregulatory complexes with their associated axonemal dynein motors provide a mechanism for the long-hypothesized mechanotransduction pathway to regulate ciliary motility. Structures of respiratory-cilia doublet microtubules from four individuals with PCD reveal how the loss of individual docking factors can selectively eradicate periodically repeating structures.

Legend

Protein

Chemical

Disease

Primary Citation of related structures
8J07
Feedback Form
Name
Email
Institute
Feedback