7UUO image
Deposition Date 2022-04-28
Release Date 2022-11-02
Last Version Date 2026-02-25
Entry Detail
PDB ID:
7UUO
Keywords:
Title:
Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.65 Å
R-Value Free:
0.32
R-Value Work:
0.28
R-Value Observed:
0.28
Space Group:
P 3
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Aminocyclitol acetyltransfera
Gene (Uniprot):apmA
Chain IDs:A, B, C
Chain Length:276
Number of Molecules:3
Biological Source:Staphylococcus aureus
Primary Citation
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Nat.Chem.Biol. 20 234 242 (2024)
DOI: 10.1038/s41589-023-01483-3
Primary Citation of related structures
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