7Q0R image
Deposition Date 2021-10-16
Release Date 2022-05-25
Last Version Date 2022-06-08
Entry Detail
PDB ID:
7Q0R
Keywords:
RIBOSOME
Title:
Structure of the Candida albicans 80S ribosome in complex with blasticidin s
Biological Source:
Source Organism(s):
Candida albicans SC5314 (Taxon ID: 237561)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.67 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
7Q0R validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L20
Gene (Uniprot):RPL20B
Chain IDs:V (auth: 0)
Chain Length:172
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PLC9 Pfam ID:PF01775
Polymer Type:polyribonucleotide
Molecule:25S ribosomal RNA
Chain IDs:A (auth: 1)
Chain Length:3359
Number of Molecules:1
Biological Source:Candida albicans SC5314
Polymer Type:polyribonucleotide
Molecule:Mixture of the endogenous E-t
Chain IDs:D (auth: 10)
Chain Length:77
Number of Molecules:1
Biological Source:Candida albicans SC5314
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL21A
Chain IDs:W (auth: 2)
Chain Length:160
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PGY0 Pfam ID:PF01157
Polymer Type:polyribonucleotide
Molecule:5S ribosomal RNA
Chain IDs:B (auth: 3)
Chain Length:121
Number of Molecules:1
Biological Source:Candida albicans SC5314
Polymer Type:polyribonucleotide
Molecule:5.8S ribosomal RNA
Chain IDs:C (auth: 4)
Chain Length:158
Number of Molecules:1
Biological Source:Candida albicans SC5314
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL22B
Chain IDs:X (auth: 5)
Chain Length:124
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PM41 Pfam ID:PF01776
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL23A
Chain IDs:Y (auth: 6)
Chain Length:137
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PPT5 Pfam ID:PF00238
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL24A
Chain IDs:Z (auth: 7)
Chain Length:155
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5A6A1 Pfam ID:PF01246
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL25
Chain IDs:AA (auth: 8)
Chain Length:142
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PPS1 Pfam ID:PF03939, PF00276
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL26B
Chain IDs:BA (auth: 9)
Chain Length:127
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PCQ5 Pfam ID:PF16906
Polymer Type:polyribonucleotide
Molecule:18S ribosomal RNA
Chain IDs:UA (auth: A)
Chain Length:105
Number of Molecules:1
Biological Source:Candida albicans SC5314
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27
Gene (Uniprot):RPL27A
Chain IDs:CA (auth: AA)
Chain Length:136
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PFG4 Pfam ID:PF01777
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL28
Chain IDs:DA (auth: AB)
Chain Length:149
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PSC5 Pfam ID:PF00828
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L29
Gene (Uniprot):RPL29
Chain IDs:EA (auth: AC)
Chain Length:63
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PF57 Pfam ID:PF01779
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL30
Chain IDs:FA (auth: AD)
Chain Length:106
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PM75 Pfam ID:PF01248
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL31B
Chain IDs:GA (auth: AE)
Chain Length:112
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PHF5 Pfam ID:PF01198
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL32
Chain IDs:HA (auth: AF)
Chain Length:131
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PPN6 Pfam ID:PF01655
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL33A
Chain IDs:IA (auth: AG)
Chain Length:107
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PHH4 Pfam ID:PF01247
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL34B
Chain IDs:JA (auth: AH)
Chain Length:122
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PDZ1 Pfam ID:PF01199
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL35
Chain IDs:KA (auth: AI)
Chain Length:120
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PK30 Pfam ID:PF00831
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36
Gene (Uniprot):RPL36
Chain IDs:LA (auth: AJ)
Chain Length:99
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PH21 Pfam ID:PF01158
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L37
Gene (Uniprot):RPL37B
Chain IDs:MA (auth: AK)
Chain Length:90
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PF45 Pfam ID:PF01907
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL38
Chain IDs:NA (auth: AL)
Chain Length:78
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PG16 Pfam ID:PF01781
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L39
Gene (Uniprot):RPL39
Chain IDs:OA (auth: AM)
Chain Length:51
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PDT4 Pfam ID:PF00832
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Rpl40bp
Gene (Uniprot):RPL40B
Chain IDs:PA (auth: AN)
Chain Length:52
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PL68 Pfam ID:PF01020
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L41
Gene (Uniprot):CXQ85_001884
Chain IDs:QA (auth: AO)
Chain Length:25
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A2V1AQU0 Pfam ID:PF05162
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL44
Chain IDs:RA (auth: AP)
Chain Length:106
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PEV4 Pfam ID:PF00935
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL43A
Chain IDs:SA (auth: AQ)
Chain Length:92
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PP14 Pfam ID:PF01780
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S0
Gene (Uniprot):RPS0
Chain IDs:VA (auth: B)
Chain Length:119
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:O42817 Pfam ID:PF00318
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S1
Gene (Uniprot):RPS1
Chain IDs:WA (auth: C)
Chain Length:82
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:P40910 Pfam ID:PF01015
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS21
Chain IDs:XA (auth: D)
Chain Length:67
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5A900 Pfam ID:PF00333, PF03719
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS3
Chain IDs:YA (auth: E)
Chain Length:251
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PSV5 Pfam ID:PF07650, PF00189
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S4
Gene (Uniprot):RPS42
Chain IDs:ZA (auth: F)
Chain Length:63
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PCI6 Pfam ID:PF08071, PF01479, PF00900, PF00467, PF16121
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS5
Chain IDs:AB (auth: G)
Chain Length:225
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5AG43 Pfam ID:PF00177
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6A
Chain IDs:BB (auth: H)
Chain Length:317
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PL99 Pfam ID:PF01092
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S7
Gene (Uniprot):RPS7A
Chain IDs:CB (auth: I)
Chain Length:267
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5AJ93 Pfam ID:PF01251
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Gene (Uniprot):RPS8A
Chain IDs:DB (auth: J)
Chain Length:206
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q59T44 Pfam ID:PF01201
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS9B
Chain IDs:EB (auth: K)
Chain Length:189
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PGY8 Pfam ID:PF00163, PF01479
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS10
Chain IDs:FB (auth: L)
Chain Length:363
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PI15 Pfam ID:PF03501
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):CAALFM_C501540WA
Chain IDs:GB (auth: M)
Chain Length:155
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PN83 Pfam ID:PF16205, PF00366
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Gene (Uniprot):RPS12
Chain IDs:HB (auth: N)
Chain Length:143
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5ADQ6 Pfam ID:PF01248
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS13
Chain IDs:IB (auth: O)
Chain Length:151
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PPE0 Pfam ID:PF08069, PF00312
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS14B
Chain IDs:JB (auth: P)
Chain Length:262
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PDT3 Pfam ID:PF00411
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS15
Chain IDs:KB (auth: Q)
Chain Length:142
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PK22 Pfam ID:PF00203
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS16A
Chain IDs:LB (auth: R)
Chain Length:220
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PCW6 Pfam ID:PF00380
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS17B
Chain IDs:MB (auth: S)
Chain Length:174
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PEY9 Pfam ID:PF00833
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS18
Chain IDs:NB (auth: T)
Chain Length:202
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PQQ5 Pfam ID:PF00416
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS19A
Chain IDs:OB (auth: U)
Chain Length:145
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PK61 Pfam ID:PF01090
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS20
Chain IDs:PB (auth: V)
Chain Length:204
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5A389 Pfam ID:PF00338
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S21
Gene (Uniprot):RPS21B
Chain IDs:QB (auth: W)
Chain Length:200
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PCG7 Pfam ID:PF01249
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S22-A
Gene (Uniprot):RPS22A
Chain IDs:RB (auth: X)
Chain Length:130
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q96W54 Pfam ID:PF00410
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS23A
Chain IDs:SB (auth: Y)
Chain Length:145
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PDU3 Pfam ID:PF00164
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):RPS24
Chain IDs:TB (auth: Z)
Chain Length:190
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5A7K0 Pfam ID:PF01282
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25B
Chain IDs:UB (auth: a)
Chain Length:105
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PNQ6 Pfam ID:PF03297
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S26
Gene (Uniprot):RPS26A
Chain IDs:VB (auth: b)
Chain Length:119
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5ALV6 Pfam ID:PF01283
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):RPS27
Chain IDs:WB (auth: c)
Chain Length:82
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PTI7 Pfam ID:PF01667
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):RPS28B
Chain IDs:XB (auth: d)
Chain Length:67
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PQN0 Pfam ID:PF01200
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 40S subunit protein
Gene (Uniprot):CAALFM_CR08480CA, orf19.6415.1
Chain IDs:YB (auth: e)
Chain Length:251
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PTR4 Pfam ID:PF00253
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S30
Gene (Uniprot):RPS30
Chain IDs:ZB (auth: f)
Chain Length:63
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PSK2 Pfam ID:PF04758
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal 40S subun
Gene (Uniprot):UBI3
Chain IDs:AC (auth: g)
Chain Length:225
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5A109 Pfam ID:PF00240, PF01599
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):ASC1
Chain IDs:BC (auth: h)
Chain Length:317
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:P83774 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:HABP4_PAI-RBP1 domain-contain
Gene (Uniprot):STM1
Chain IDs:TA (auth: i)
Chain Length:267
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PK71 Pfam ID:PF09598
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL2
Chain IDs:E (auth: j)
Chain Length:206
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PF08 Pfam ID:PF00181, PF03947
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Gene (Uniprot):RPL3
Chain IDs:F (auth: k)
Chain Length:189
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q59LS1 Pfam ID:PF00297
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL4B
Chain IDs:G (auth: l)
Chain Length:363
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PFV1 Pfam ID:PF00573, PF14374
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL5
Chain IDs:H (auth: m)
Chain Length:155
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5AGZ7 Pfam ID:PF17144, PF14204
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L6
Gene (Uniprot):RPL6
Chain IDs:I (auth: n)
Chain Length:143
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PCX8 Pfam ID:PF01159
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL7A
Chain IDs:J (auth: o)
Chain Length:151
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PDL6 Pfam ID:PF08079, PF00327
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L8
Gene (Uniprot):RPL8B
Chain IDs:K (auth: p)
Chain Length:262
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5ANA1 Pfam ID:PF01248
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL9B
Chain IDs:L (auth: q)
Chain Length:142
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5AEN2 Pfam ID:PF00347
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL10
Chain IDs:M (auth: r)
Chain Length:220
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5AIB8 Pfam ID:PF00252
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL11
Chain IDs:N (auth: s)
Chain Length:174
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PHW1 Pfam ID:PF00281, PF00673
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L13
Gene (Uniprot):RPL13
Chain IDs:O (auth: t)
Chain Length:202
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:O59931 Pfam ID:PF01294
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL14
Chain IDs:P (auth: u)
Chain Length:145
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PFL9 Pfam ID:PF01929
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L15
Gene (Uniprot):RPL15A
Chain IDs:Q (auth: v)
Chain Length:204
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5A6R1 Pfam ID:PF00827
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL16A
Chain IDs:R (auth: w)
Chain Length:200
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q5AB87 Pfam ID:PF00572
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL17B
Chain IDs:S (auth: x)
Chain Length:130
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:Q59TE0 Pfam ID:PF00237
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal 60S subunit protein
Gene (Uniprot):RPL18
Chain IDs:T (auth: y)
Chain Length:145
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PK43 Pfam ID:PF17135
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L19
Gene (Uniprot):RPL19A
Chain IDs:U (auth: z)
Chain Length:190
Number of Molecules:1
Biological Source:Candida albicans SC5314
UniProt ID:A0A1D8PK40 Pfam ID:PF01280, PF25476
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
MLZ Y LYS modified residue
OMC A C modified residue
OMG A G modified residue
Ligand Molecules
BLS
SPD
ZN
Primary Citation
E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv 8 eabn1062 eabn1062 (2022)
PMID: 35613268 DOI: 10.1126/sciadv.abn1062

Abstact

Candida albicans is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. It is known to be resistant to cycloheximide (CHX) that binds to the E-transfer RNA binding site of the ribosome. Because of lack of structural information, it is neither possible to understand the nature of the resistance nor to develop novel inhibitors. To overcome this issue, we determined the structure of the vacant C. albicans 80S ribosome at 2.3 angstroms and its complexes with bound inhibitors at resolutions better than 2.9 angstroms using cryo-electron microscopy. Our structures reveal how a change in a conserved amino acid in ribosomal protein eL42 explains CHX resistance in C. albicans and forms a basis for further antifungal drug development.

Legend

Protein

Chemical

Disease

Primary Citation of related structures
7PZY
7Q0F
7Q08
7Q0P
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