ISDA: 2YLY

Deposition Date 2011-06-06

Release Date 2012-06-13

Last Version Date 2024-05-08

Entry Detail

PDB ID:

2YLY

Keywords:

RECEPTOR

Title:

Sulfonamides as selective Estrogen Receptor beta Agonists.

Biological Source:

Source Organism(s):

HOMO SAPIENS (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.20 Å

R-Value Free:

0.27

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

I 4 2 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ESTROGEN RECEPTOR BETA
Gene (Uniprot):ESR2
Chain IDs:A, B
Chain Length:240
Number of Molecules:2
Biological Source:HOMO SAPIENS

UniProt ID:Q92731 Pfam ID:PF00104

Ligand Molecules

SO4

SU4

Primary Citation

Sulfonamides as Selective Oestrogen Receptor Beta Agonists.

Roberts, L.R, Armor, D, Barker, C, Bent, A, Bess, K, Brown, A, Favor, D.A, Ellis, D, Irving, S.L, Mackenny, M, Phillips, C, Pullen, N, Stennett, A, Strand, L, Styles, M.Show

Bioorg.Med.Chem.Lett. 21 5680 ? (2011)

PMID: 21885279 DOI: 10.1016/J.BMCL.2011.08.041

Abstact

A series of p-hydroxybenzenesulphonamides ERβ receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERα receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERβ agonists.

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Protein

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Disease

Primary Citation of related structures

Abstact

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