ISDA: 28OQ

Deposition Date 2026-02-11

Release Date 2026-04-01

Last Version Date 2026-04-01

Entry Detail

PDB ID:

28OQ

Keywords:

TRANSFERASE

Title:

Protein Kinaze domain PAK1 complexed with NVS inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.28 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):PAK1
Chain IDs:A (auth: B), B (auth: A)
Chain Length:297
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q13153 Pfam ID:PF00069 EC:2.7.11.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
TPO	A	THR	modified residue

Ligand Molecules

A1JZR

GOL

Primary Citation

Rational Discovery of Therapeutic PAK1 Allosteric Activators

Yu, H.Show

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Primary Citation of related structures

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