ISDA: 28KD

Deposition Date 2026-02-04

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

28KD

Keywords:

HYDROLASE

Title:

ACE2 extracellular domain in complex with the macrocyclic peptide GR3.1.2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Synthetic plasmid (Taxon ID: 1440148)

Expression System(s):

Escherichia coli bl21(de3), Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.02 Å

R-Value Free:

0.27

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Processed angiotensin-convert
Gene (Uniprot):ACE2
Chain IDs:A (auth: B), C (auth: A)
Chain Length:609
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9BYF1 Pfam ID:PF01401 EC:3.4.15.1

Polymer Type:polypeptide(L)
Molecule:ALA-CYS-PHE-LEU-ARG-CYS-HIS-A
Chain IDs:B (auth: C), D
Chain Length:18
Number of Molecules:2
Biological Source:Synthetic plasmid

Ligand Molecules

Primary Citation

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.

Romanyuk, Z, Bettin, G, Brear, P, Linciano, S, Mazzocato, Y, Bonadies, S, Zanotto, I, Mazzucco, C, Monferone, A, Soler, M.A, Pasut, G, Martin, S, Scarso, A, Heinis, C, Rothenberger, S, Hyvonen, M, Angelini, A.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41875055 DOI: 10.1021/acs.jmedchem.5c02876

Primary Citation of related structures

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