ISDA: 23OM

Deposition Date 2026-02-12

Release Date 2026-02-25

Last Version Date 2026-03-25

Entry Detail

PDB ID:

23OM

Keywords:

LYASE

Title:

Crystal Structure Analysis of Bovine Carbonic Anhydrase II to 5-(2-morpholin-4-ylcarbonyl-1,3-oxazol-5-yl)thiophene-2-sulfonamide.

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.70 Å

R-Value Free:

0.25

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Carbonic anhydrase 2
Gene (Uniprot):CA2
Chain IDs:A, B
Chain Length:259
Number of Molecules:2
Biological Source:Bos taurus

UniProt ID:P00921 Pfam ID:PF00194 EC:4.2.1.1

Ligand Molecules

8V5

ACT

BOG

GOL

SO4

Primary Citation

X-ray analysis of complexes of carbonic anhydrase II with 1,3-oxazole-containing sulfonamide derivatives elucidates the structural basis for their exceptionally high inhibitory potency.

Stoliarskaia, M.Y, Borisevich, S.S, Myaskov, E.O, Shetnev, A.A, Korsakov, M.K, Nikonov, O.S.Show

Acta Crystallogr.,Sect.F ? ? ? (2026)

PMID: 41834583 DOI: 10.1107/S2053230X26002128

Primary Citation of related structures

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