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Deposition Date 2025-12-24
Release Date 2026-03-25
Last Version Date 2026-03-25
Entry Detail
PDB ID:
21TP
Keywords:
MEMBRANE PROTEIN
Title:
Open-state structure of veratridine-activated human Nav1.7
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
21TP validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium channel protein type 9
Gene (Uniprot):SCN9A
Chain IDs:A
Chain Length:1988
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15858 Pfam ID:PF00520, PF11933, PF06512, PF24609
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium channel regulatory sub
Gene (Uniprot):SCN1B
Chain IDs:B
Chain Length:173
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q07699 Pfam ID:PF07686
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sodium channel regulatory sub
Gene (Uniprot):SCN2B
Chain IDs:C
Chain Length:119
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O60939 Pfam ID:PF07686
Ligand Molecules
A1E26
LPE
NAG
PCW
Y01
Primary Citation
Open-state structure of veratridine-activated human Nav1.7 reveals the molecular choreography of fast inactivation
To Be Published ? ? ? (?)
Primary Citation of related structures
21TP
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