ISDA: 21AG

Deposition Date 2025-12-04

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

21AG

Keywords:

MEMBRANE PROTEIN/IMMUNE SYSTEM

Title:

LY334370-bound serotonin 1F (5-HT1F) receptor-miniGoA protein complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.13 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:A (auth: B)
Chain Length:358
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAO1
Chain IDs:B (auth: C)
Chain Length:228
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P09471 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:5-hydroxytryptamine receptor
Gene (Uniprot):HTR1F
Chain IDs:D (auth: R)
Chain Length:366
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P30939 Pfam ID:PF00001

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:E (auth: S)
Chain Length:267
Number of Molecules:1
Biological Source:Mus musculus

Ligand Molecules

A1E2G

Primary Citation

Structural basis of LY334370 recognition and selectivity at the 5-HT 1F receptor.

Wang, Y, Wang, C, Cao, C.Show

Biochem.Biophys.Res.Commun. 804 153313 153313 (2026)

PMID: 41619505 DOI: 10.1016/j.bbrc.2026.153313

Primary Citation of related structures

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