11OU image
Deposition Date 2026-03-06
Release Date 2026-04-08
Last Version Date 2026-04-08
Entry Detail
PDB ID:
11OU
Keywords:
IMMUNE SYSTEM
Title:
Omi32 germline Fab in complex with LC-Kappa VHH
Biological Source:
Source Organism(s):
Lama glama (Taxon ID: 9844)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Saccharomyces cerevisiae, Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
11OU validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Omi32 germline heavy chain
Chain IDs:C (auth: H)
Chain Length:219
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:LC-Kappa VHH
Chain IDs:A (auth: K)
Chain Length:120
Number of Molecules:1
Biological Source:Lama glama
Polymer Type:polypeptide(L)
Molecule:Omi32 germline light chain
Chain IDs:B (auth: L)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis.
Biorxiv ? ? ? (2026)
PMID: 41889954 DOI: 10.64898/2026.03.12.711465
Primary Citation of related structures
11OU
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