10ZO image
Deposition Date 2026-02-12
Release Date 2026-03-25
Last Version Date 2026-03-25
Entry Detail
PDB ID:
10ZO
Keywords:
IMMUNE SYSTEM/VIRAL PROTEIN
Title:
Crystal structure of Mengla virus nucleoprotein bound by a cross-reactive anti-Marburg virus nanobody
Biological Source:
Source Organism(s):
Lama glama (Taxon ID: 9844)
Dianlovirus menglaense (Taxon ID: 3052181)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.65 Å
R-Value Free:
0.21
R-Value Work:
0.16
R-Value Observed:
0.16
Space Group:
H 3 2
10ZO validation report
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Anti-Marburgvirus Nucleoprote
Chain IDs:A, C
Chain Length:118
Number of Molecules:2
Biological Source:Lama glama
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nucleoprotein
Gene (Uniprot):NP
Chain IDs:B, D
Chain Length:106
Number of Molecules:2
Biological Source:Dianlovirus menglaense
UniProt ID:A0A1Q1NMU1 Pfam ID:PF05505
Primary Citation
Crystal Structure of Mengla Virus Nucleoprotein Bound by a Poorly Cross-Reactive Anti-Marburg Virus Nanobody Highlights a Single Amino Acid Affinity Switch, a Feature Also Evident in Dehong Virus.
Acs Infect Dis. 12 1104 1121 (2026)
PMID: 41760080 DOI: 10.1021/acsinfecdis.5c00920
Primary Citation of related structures
10ZO
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